Higher triglyceride to high‐density lipoprotein cholesterol ratio increases cardiovascular risk: 10‐year prospective study in a cohort of Chinese adults

Autor: Zefeng Cai, Youren Chen, Jianhuan Huang, Guanzhi Chen, Haojia Chen, Hai-lun Qin, Zekai Chen, Zhichao Chen, Shouling Wu, Weiqiang Wu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
China
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Diseases of the endocrine glands. Clinical endocrinology
Cardiovascular risks
03 medical and health sciences
Triglyceride to high‐density lipoprotein cholesterol ratio
0302 clinical medicine
Asian People
Risk Factors
Internal medicine
Internal Medicine
Medicine
Humans
Cumulative incidence
Myocardial infarction
Prospective Studies
Prospective cohort study
Stroke
Triglycerides
Proportional Hazards Models
Chinese
business.industry
Incidence (epidemiology)
Hazard ratio
Cholesterol
HDL
General Medicine
Articles
Middle Aged
RC648-665
medicine.disease
Clinical Science and Care
Cardiovascular Diseases
Cohort
Original Article
Female
business
Cohort study
Zdroj: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 11, Iss 2, Pp 475-481 (2020)
ISSN: 2040-1124
2040-1116
Popis: Aims/Introduction A higher ratio of triglyceride to high‐density lipoprotein cholesterol (TG/HDL‐C) is considered as the independent risk index of cardiovascular (CV) events. However, cohort studies regarding this correlation are rarely reported, especially in the Chinese population. The aim of present study was to explore the relationship of the TG/HDL‐C ratio with CV risks among Chinese adults during 10‐year follow‐up period. Materials and Methods We carried out a prospective study using data obtained from 96,542 individuals in Kailuan, who were grouped through the median value (0.8533) of the TG/HDL‐C ratio. Adverse outcomes mainly referred to major CV events. We used the person‐years incidence and cumulative incidence to predict the morbidity. The risk of CV events was estimated through Cox proportional hazard models. Results The mean age of the cohort was 51.5 ± 12.6 years, and 79.6% of participants were men. During a median follow‐up period of 9.75 years, 5,422 major CV events occurred, including 1,312 myocardial infarction cases and 4,228 stroke cases. The cumulative incidence of myocardial infarction, stroke and total CV events was 1.36% (range 1.29–1.43%), 4.38% (range 4.25–4.51%) and 5.62% (range 5.47–5.76%), respectively. Compared with low the TG/HDL‐C ratio (≤0.8533) group, the high TG/HDL‐C ratio (>0.8533) group had higher morbidity of CV events. The hazard ratio of total CV events, stroke and myocardial infarction was 1.19 (95% CI 1.12–1.26), 1.11 (95% CI 1.03–1.18) and 1.50 (95% CI 1.33–1.70), respectively. Furthermore, the TG/HDL‐C ratio and major CV events had a line‐shaped relationship with each other. Conclusions Among the Chinese population, a higher TG/HDL‐C ratio is correlated with an increased risk of major CV events.
This is the first large prospective cohort study regarding the association of the triglyceride to high‐density lipoprotein cholesterol (TG/HDL‐C) ratio with major cardiovascular events among Chinese individuals. Among the Chinese population, an elevated TG/HDL‐C ratio is associated with an increased risk of major cardiovascular events.
Databáze: OpenAIRE
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