Activation of the Jak-Stat Pathway in Cells That Exhibit Selective Sensitivity to the Antiviral Effects of IFN-beta Compared with IFN-alpha
| Autor: | Hans R. Figulla, Oscar R. Colamonici, Eleanor N. Fish, Albert Heim, Beata Majchrzak, Shahab Uddin, Leonidas C. Platanias, Isabella M. Grumbach |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
STAT3 Transcription Factor
Immunology Biology Antiviral Agents Ifn alpha 03 medical and health sciences Virology Humans Beta (finance) Cells Cultured 030304 developmental biology 0303 health sciences 030302 biochemistry & molecular biology Interferon-alpha Janus Kinase 3 JAK-STAT signaling pathway STAT2 Transcription Factor Interferon-beta Cell Biology Protein-Tyrosine Kinases Molecular biology DNA-Binding Proteins Enzyme Activation STAT1 Transcription Factor Trans-Activators Signal Transduction |
| Zdroj: | Journal of Interferon & Cytokine Research. 19:797-801 |
| ISSN: | 1557-7465 1079-9907 |
| DOI: | 10.1089/107999099313659 |
| Popis: | We determined whether selective activation of components of the Jak-Stat pathway by different type I interferons (IFN) occurs in human myocardial fibroblasts that exhibit much higher sensitivity to the antiviral effects of IFN-beta than of IFN-alpha. Similar levels of activation of the Tyk2 kinase and the Stat3 transcription factor were induced in response to either IFN-beta or IFN-alpha treatment. However, activation of the Jak1 tyrosine kinase was detectable only in IFN-beta-treated but not IFN-alpha-treated cells. Consistent with this, tyrosine phosphorylation of Stat1 and Stat2 and formation of the IFN-stimulated gene factor 3 (ISGF3) complex occurred to a much higher degree in response to IFN-beta stimulation. These findings demonstrate that differential activation of distinct components of the Jak-Stat pathway by different type I IFN can occur. Furthermore, they strongly suggest that such selective activation accounts for the occurrence of differences in the antiviral properties of distinct type I IFN in certain cell types. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|