Investigation of Appropriate Inhalation Technique for Mometasone Furoate Dry Powder Inhaler
| Autor: | Hirokazu Mihashi, Yasuhiko Yamada, Yasuyuki Shiraishi, Risa Takayanagi, Kanako Ito, Haruko Yokoyama |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Lung deposition
Anti-Inflammatory Agents Pharmaceutical Science Mometasone furoate 02 engineering and technology 03 medical and health sciences 0302 clinical medicine Administration Inhalation Anti-Allergic Agents medicine Humans Lung Cascade impactor Pharmacology Inhalation Chemistry Dry Powder Inhalers General Medicine Peak Inspiratory Flow Rate 021001 nanoscience & nanotechnology Dry-powder inhaler Inhalation technique 030228 respiratory system Anesthesia 0210 nano-technology Pulmonary Ventilation Mometasone Furoate medicine.drug Particle fraction |
| Zdroj: | Biologicalpharmaceutical bulletin. 39(10) |
| ISSN: | 1347-5215 |
| Popis: | The aim of this study was to establish an appropriate inhalation method with a mometasone furoate dry powder inhaler (MF-DPI). Utilizing a tone-based inhalation training device, we investigated the maximum peak inspiratory flow rate time (Tmax PIFR) and peak inspiratory flow rate (PIFR) to determine whether either had an influence on lung deposition with use of an MF-DPI. A low tone indicated a PIFR of 28 L/min and a high tone that of 40 L/min, while 60 L/min was considered to be the standard. We established an inhalation profile in consideration of a human inhalation pattern, in which Tmax PIFR was set at 0.5 s (Tmax PIFR 0.5 s) and 2.5 s (Tmax PIFR 2.5 s). The reference cut-off value derived with a cascade impactor test was used for evaluation of the rate of delivered dose in the lung, which was the amount of drug from stage 3 to 7 at all PIFRs. We then investigated the relationship of the fine particle fraction (FPF) with the claimed dose at Tmax PIFR of 0.5 s and PIFR. There were no differences among the Tmax PIFR values for the doses emitted from the device or for the rate of delivered doses in stages 3-7. However, FPF for the claimed dose at 40 L/min was significantly lower than that at 60 L/min, which was dependent on PIFR. Our results showed that PIFR but not Tmax PIFR has an effect on lung deposition after inhalation with an MF-DPI. |
| Databáze: | OpenAIRE |
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