Immunological aspects of surgically induced experimental endometriosis: variation in response to therapy
| Autor: | Robert J. Homm, David E. Garza, H. Oliver Williamson, Billy Baggett, Subbi Mathur, Marshal Austin |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Pathology Blotting Western Endometriosis Endometrium Autoantigens Immune system Antigen Internal medicine medicine Animals Autoantibodies Estradiol biology business.industry Peritoneal fluid Antibody titer Autoantibody Obstetrics and Gynecology Hemagglutination Tests medicine.disease Molecular Weight Disease Models Animal medicine.anatomical_structure Endocrinology Reproductive Medicine biology.protein Female Rabbits Antibody business |
| Zdroj: | Fertility and Sterility. 52:132-139 |
| ISSN: | 0015-0282 |
| Popis: | Elevated endometrial antibody titers were detected in serum and peritoneal fluid of rabbits with experimentally induced endometriosis. Surgical extirpation of implants or suppression with gonadotropin-releasing hormone agonist resulted in decreased endometrial antibody titers, whereas the antibody titers in untreated rabbits with endometriosis increased significantly. Endometrial implants and normal endometrial tissue had similar proteins by polyacrylamide gel electrophoresis. However, the serum and peritoneal fluid from rabbits with experimentally induced endometriosis had gamma G immunoglobulin antibodies to an endometrial protein with molecular weight of approximately 40 kD. These antibodies were absent in rabbits without endometriosis. Isolation of endometrial antigens eliciting the humoral immune response in endometriosis may aid in the development of a specific antibody marker for endometriosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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