Successful treatment of adult T-cell leukemia with unrelated cord blood transplantation
| Autor: | Toshiki Kitajima, Keiichiro Honma, Hidenobu Takahashi, Sadao Aoki, Tatsuo Furukawa, Tori Kurasaki, Masutaka Higashimura, Akihito Momoi, Naoya Nakamura, Jun Takizawa, Yoshifusa Aizawa |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
medicine.medical_specialty Cyclophosphamide viruses T-cell leukemia Peripheral blood mononuclear cell HLA Antigens hemic and lymphatic diseases Internal medicine Medicine Humans Leukemia-Lymphoma Adult T-Cell Transplantation Homologous Skin Hematology business.industry Total body irradiation Middle Aged medicine.disease Fetal Blood Transplantation Leukemia Treatment Outcome Immunology Cytarabine Female Cord Blood Stem Cell Transplantation business medicine.drug |
| Zdroj: | American journal of hematology. 82(12) |
| ISSN: | 0361-8609 |
| Popis: | This study reports the first well-documented case of adult T-cell leukemia (ATL) successfully treated with unrelated cord blood transplantation (UCBT). A 49-year-old woman was diagnosed with acute-type of ATL. Chemotherapy induced complete remission, but the human T-cell leukemia virus type 1 (HTLV-1) proviral load was detected in mononuclear cells of her peripheral blood. The patient received UCBT with a conditioning regimen consisting of total body irradiation, cytarabine, and cyclophosphamide. She remains in remission 30 months after UCBT and the HTLV-1 proviral load has fallen to undetectable levels. This result suggests that UCBT should be a therapeutic option for ATL patients who do not have suitable donors and those who urgently require treatment. |
| Databáze: | OpenAIRE |
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