Modified natural cycle IVF versus conventional stimulation in advanced-age Bologna poor responders
| Autor: | Panagiotis Drakopoulos, Alessia Romito, Christophe Blockeel, Joaquín Errázuriz, Samuel Santos-Ribeiro, Herman Tournaye, Annalisa Racca, Michel De Vos, B. Popovic-Todorovic |
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| Přispěvatelé: | Surgical clinical sciences, Centre for Reproductive Medicine - Gynaecology, Biology of the Testis, Follicle Biology, Reproduction and Genetics |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Referral Pregnancy Rate medicine.medical_treatment Poor responder Drug Resistance Fertilization in Vitro Logistic regression Intracytoplasmic sperm injection 03 medical and health sciences 0302 clinical medicine Ovulation Induction Pregnancy medicine Humans Treatment Failure Birth Rate Menstrual Cycle Ovarian Function Tests Retrospective Studies 030219 obstetrics & reproductive medicine Obstetrics business.industry Patient Selection Confounding Infant Newborn Obstetrics and Gynecology Retrospective cohort study Odds ratio Fertility Agents Female Confidence interval 030104 developmental biology Reproductive Medicine Research Design Female business Infertility Female Developmental Biology Maternal Age |
| Popis: | Research question Do ongoing pregnancy rates (OPR) differ between modified natural cycle IVF (MNC-IVF) and conventional high-dose ovarian stimulation (HDOS) in advanced-age Bologna poor responders? Design This was a retrospective cohort study including patients with poor ovarian response (POR) attending a tertiary referral university hospital from 1 January 2011 to 1 March 2017. All women who fulfilled the Bologna criteria for POR and aged ≥40 years who underwent their first intracytoplasmic sperm injection (ICSI) cycle in the study centre were included. Results In total, 476 advanced-age Bologna poor responder patients were included in the study: 189 in the MNC-IVF group and 287 in the HDOS group. OPR per patient were significantly lower in the MNC-IVF group (5/189, 2.6%) compared with the HDOS group (29/287, 10.1%) (P = 0.002). However, after adjustment for relevant confounders (number of oocytes and presence of at least one top-quality embryo), the multivariate logistic regression analysis showed that the type of treatment strategy (HDOS versus MNC-IVF) was not significantly associated with OPR (odds ratio 2.56, 95% confidence interval 0.9–7.6). Conclusions In advanced-age Bologna poor responders, MNC-IVF, which is a more patient-friendly approach, could be a reasonable alternative in this difficult-to-treat group of women. |
| Databáze: | OpenAIRE |
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