COVID-19-related organ dysfunction and management strategies on the intensive care unit: a narrative review
| Autor: | Marlies Ostermann, Luigi Camporota, Nicholas Ioannou, Peter B. Sherren, Christopher I. S. Meadows, Sangita Agarwal |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
ARDS
medicine.medical_specialty Critical Care Multiple Organ Failure Pneumonia Viral Review Article MODS Experiential learning law.invention 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology law Intensive care Pandemic medicine Humans Disease management (health) Intensive care medicine Pandemics business.industry SARS-CoV-2 ventilation Organ dysfunction respiratory failure COVID-19 Disease Management medicine.disease Intensive care unit Anesthesiology and Pain Medicine Respiratory failure medicine.symptom ECMO business Coronavirus Infections |
| Zdroj: | British Journal of Anaesthesia BJA: British Journal of Anaesthesia |
| ISSN: | 0007-0912 |
| DOI: | 10.1016/j.bja.2020.08.050 |
| Popis: | The coronavirus disease 2019 (COVID-19) pandemic has resulted in a significant surge of critically ill patients and an unprecedented demand on intensive care services. The rapidly evolving understanding of pathogenesis, limited disease specific evidence, and demand-resource imbalances have posed significant challenges for intensive care clinicians. COVID-19 is a complex multisystem inflammatory vasculopathy with a significant mortality implication for those admitted to intensive care. Institutional strategic preparation and meticulous intensive care support are essential to maximising outcomes during the pandemic. The significant mortality variation observed between institutions and internationally, despite a single aetiology and uniform presentation, highlights the potential influence of management strategies on outcome. Given that optimal organ support and adjunctive therapies for COVID-19 have not yet been well defined by trial-based outcomes, strategies are predicated on existing literature and experiential learning. This review outlines the relevant pathophysiology and management strategies for critically ill patients with COVID-19, and shares some of the collective learning accumulated in a high volume severe respiratory failure centre in London. |
| Databáze: | OpenAIRE |
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