Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts
| Autor: | Takeo Yoshikawa, Tomoko Toyota, Taiichi Katayama, Norio Mori, Kousuke Baba, Ko Miyoshi, Yoshimi Iwayama-Shigeno, Eiji Hattori, Kazuo Yamada, Akiko Honda, Yoshimoto Sekine, Kazuhiko Nakamura, Masaya Tohyama, Katsuaki Suzuki, Yasuhide Iwata, Yoshio Minabe, Hitomi Takao, Noriyoshi Takei |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Linkage disequilibrium Psychosis Bipolar Disorder Genotype DNA Mutational Analysis Nerve Tissue Proteins Single-nucleotide polymorphism Polymorphism Single Nucleotide Linkage Disequilibrium Cohort Studies DISC1 Asian People Gene Frequency mental disorders medicine Humans Genetic Predisposition to Disease Bipolar disorder Allele frequency Polymorphism Single-Stranded Conformational Biological Psychiatry Adaptor Proteins Signal Transducing Aged Genetic association Genetics Chi-Square Distribution biology Tumor Suppressor Proteins Genetic Variation Middle Aged medicine.disease DNA-Binding Proteins Schizophrenia Case-Control Studies biology.protein Female Psychology |
| Zdroj: | Biological Psychiatry. 56:683-690 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2004.08.015 |
| Popis: | Background DISC1 has been suggested as a causative gene for psychoses in a large Scottish family. We recently identified FEZ1 as an interacting partner for DISC1. To investigate the role of FEZ1 in schizophrenia and bipolar disorder, case–control association analyses were conducted in Japanese cohorts. Methods We performed a mutation screen of the FEZ1 gene and detected 15 polymorphisms. Additional data on informative polymorphisms were obtained from public databases. Eight single nucleotide polymorphisms (SNPs) were analyzed in 119 bipolar disorder and 360 schizophrenic patients and age- and gender-matched control subjects. All genotypes were determined with the TaqMan assay, and selected samples were confirmed by sequencing. Results The two adjacent polymorphisms displayed a nominally significant association with schizophrenia (IVS2+1587G>A, p = .014; 396T p = .024). Homozygotes with the Glu123 allele were observed in only a small portion (2%) of schizophrenia patients but not in control subjects or bipolar patients. Conversely, no SNPs displayed allelic, genotypic, or haplotypic associations with bipolar disorder. Conclusions A modest association between FEZ1 and schizophrenia suggests that this gene and the DISC1-mediated molecular pathway might play roles in the development of schizophrenia, with FEZ1 affecting only a small subset of Japanese schizophrenia patients. |
| Databáze: | OpenAIRE |
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