The protective effect of Rubus fruticosus L. on blood composition in cyclophosphamide treated male rats
Autor: | Abdolkarim Hosseini, Zahra Izadi, Ida Shahabi Baher, Naser Mirazi |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Cyclophosphamide
medicine.medical_treatment lcsh:Medicine lcsh:RX1-681 Hematocrit Pharmacology 03 medical and health sciences 0302 clinical medicine lcsh:Homeopathy medicine Platelet Bone marrow Saline Rubus fruticosus 030304 developmental biology General Environmental Science 0303 health sciences medicine.diagnostic_test business.industry Hematopoietic Tissue lcsh:R Hematopoiesis medicine.anatomical_structure General Earth and Planetary Sciences 030211 gastroenterology & hepatology Hemoglobin Rubus fruticosus L business medicine.drug |
Zdroj: | Clinical Phytoscience, Vol 7, Iss 1, Pp 1-7 (2021) |
ISSN: | 2199-1197 |
Popis: | Background Some chemotherapy drugs such cyclophosphamide (CP) has destructive effects on hematopoietic cells in the bone marrow tissue. Due to antioxidant and anti-inflammatory features, medicinal herbs have protective effects on the bone marrow tissue. The aim of this experimental study is to examine the protective effects of Rubus fruticosus L. extract (RF) on blood parameters in male rats treated with CP. Methods In this experimental study, 35 male Wistar rats (220–250 g) were randomly divided into 5 groups (n = 7): Control (0.5 mL normal saline), CP (15 mg/kg), positive control (RF per se 200 mg/kg), treatment 1 (CP 15 mg/kg + RF 100 mg/kg), and treatment 2 (CP 15 mg/kg + RF 200 mg/kg). All drugs and extracts were given intraperitoneally for 15 consecutive days. At the end of the intervention, all animals were euthanized and their blood samples were collected by cardiac puncture in anti-coagulant tubes for blood parameters evaluation. Results The data analysis showed that CP has decreased significantly in RBC, WBC, Platelets number, hemoglobin and hematocrit in rats (p Conclusion The use of RF can protect the blood hematopoietic tissue in bone marrow and prevent CP toxic effects. |
Databáze: | OpenAIRE |
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