Effect of renal function on neutrophil decreases following eribulin administration
| Autor: | Masayuki Endo, Hirotoshi Murakami, Hiroyuki Tanaka, Kenichi Watanabe, Nobumoto Tomioka, Masato Takahashi, Suzuki Norifumi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Neutropenia Neutrophils Serum albumin Urology Renal function Breast Neoplasms Kidney Leukocyte Count chemistry.chemical_compound Breast cancer Quality of life medicine Humans Treatment Failure Furans Time to treatment failure Aged Retrospective Studies biology business.industry Albumin Original Articles Ketones Middle Aged medicine.disease Renal Elimination Oncology chemistry Toxicity Disease Progression biology.protein Female Neoplasm Recurrence Local business Glomerular Filtration Rate Eribulin |
| Zdroj: | Cancer Rep (Hoboken) |
| ISSN: | 2573-8348 |
| DOI: | 10.1002/cnr2.1258 |
| Popis: | BACKGROUND: Eribulin therapy has recently attracted attention from various viewpoints, including quality of life, and is considered a standard therapy for inoperable or recurrent breast cancer. Although a reduction in renal function reportedly decreases total eribulin clearance, its association with dose‐limiting toxicity and the reduction of neutrophils remain unclear. AIM: This study was aimed at analyzing the association between decreased renal function prior to eribulin administration and the occurrence of neutrophil reduction and time to treatment failure in patients with breast cancer. METHODS AND RESULTS: We retrospectively assessed patients with breast cancer, who underwent eribulin therapy between July 2011 and March 2018. Multivariate analysis revealed creatinine clearance |
| Databáze: | OpenAIRE |
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