Pharmacology of Adenosine Receptors: The State of the Art
| Autor: | Fabrizio Vincenzi, Stefania Gessi, Stefania Merighi, Katia Varani, Pier Andrea Borea |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adenosine Physiology Socio-culturale inflammatory diseases Endogeny Pharmacology 03 medical and health sciences Neoplasms Physiology (medical) Purinergic P1 Receptor Agonists medicine Animals Humans cancer pain neurodegenerative diseases autoimmune diseases Receptor Molecular Biology Molecular Structure Chemistry Receptors Purinergic P1 General Medicine Adenosine receptor adenosine receptors 030104 developmental biology Purinergic P1 Receptor Antagonists Cardiovascular Diseases adenosine receptors pain cancer neurodegenerative diseases inflammatory diseases autoimmune diseases Nervous System Diseases Signal transduction Autacoid Adenosine metabolism Signal Transduction medicine.drug |
| Zdroj: | Physiological Reviews. 98:1591-1625 |
| ISSN: | 1522-1210 0031-9333 |
| DOI: | 10.1152/physrev.00049.2017 |
| Popis: | Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid generation of adenosine from cellular metabolism, and the widespread distribution of its receptor subtypes in almost all organs and tissues, this nucleoside induces a multitude of physiopathological effects, regulating central nervous, cardiovascular, peripheral, and immune systems. It is becoming clear that the expression patterns of adenosine receptors vary among cell types, lending weight to the idea that they may be both markers of pathologies and useful targets for novel drugs. This review offers an overview of current knowledge on adenosine receptors, including their characteristic structural features, molecular interactions and cellular functions, as well as their essential roles in pain, cancer, and neurodegenerative, inflammatory, and autoimmune diseases. Finally, we highlight the latest findings on molecules capable of targeting adenosine receptors and report which stage of drug development they have reached. |
| Databáze: | OpenAIRE |
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