Acetyl-l-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy
| Autor: | Carla Ghelardini, E. Vivoli, Alberto Salvicchi, A. Bartolini, Raffaella Nicolai, Paola Benatti, Aleardo Koverech, L. Di Cesare Mannelli |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pain Threshold Nervous system medicine.medical_specialty Central nervous system Artemin Pain Nerve Tissue Proteins Constriction Pathologic Rats Sprague-Dawley Neurotrophic factors Ganglia Spinal Internal medicine medicine Glial cell line-derived neurotrophic factor Animals Periaqueductal Gray Nerve Growth Factors Analgesics biology business.industry General Neuroscience Peripheral Nervous System Diseases Sciatic Nerve Rats Neuroprotective Agents medicine.anatomical_structure Endocrinology Spinal Cord nervous system Anesthesia Neuropathic pain Hyperalgesia biology.protein medicine.symptom Acetylcarnitine business Neurotrophin |
| Zdroj: | Neuroscience. 167:1168-1174 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2010.03.017 |
| Popis: | Damages to the nervous system are the primarily cause of neuropathy and chronic pain. Current pharmacological treatments for neuropathic pain are not able to prevent or revert morphological and molecular consequences of tissue injury. On the other hand, many neurotrophins, like nerve growth factor (NGF), paired off restorative effects with hyperalgesia. Interestingly, the glial cell line-derived neurotrophic factors GDNF and Artemin (ARTN) seem to support neuron survival and to normalize abnormal pain behaviour. In the present research protein levels of NGF, GDNF and ARTN were evaluated in a rat model of peripheral neuropathy, the chronic constriction injury (CCI). NGF was increased by CCI in the ipsilateral dorsal root ganglia (DRG), in the spinal cord and in the periaqueductal grey matter (PAG). On the contrary, ARTN was decreased bilaterally in DRG, spinal cord and PAG. GDNF levels decreased in ipsilateral DRG, whereas the constriction did not modify its expression in the central nervous system districts. Repeated treatments with the antihyperalgesic and neuroregenerative compound acetyl-l-carnitine (ALCAR; 100 mgkg(-1) i.p. twice daily for 15 days) was able to prevent the increase of NGF levels. In conditions of pain relief ALCAR normalized peripheral and central alterations of GDNF and ARTN levels. Characteristically, sham animals that underwent the same ALCAR treatment, showed increased levels of ARTN both in the DRG and in the spinal cord. These data offer a new point of view on the mechanism of the antihyperalgesic as well as the neuroprotective effect of ALCAR. |
| Databáze: | OpenAIRE |
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