The protective capacity of high payload FMDV A22 IRQ vaccine in sheep against direct-contact challenge with a heterologous, contemporary FMDV A strain from South East Asia
| Autor: | Charles Nfon, Hilary Bittner, Nagendrakumar B. Singanallur, Wilna Vosloo, Peter A. Durr, Jacquelyn Horsington, Soren Alexandersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology lcsh:Medicine Disease Biochemistry Animal Diseases 0403 veterinary science Immune Physiology Medicine and Health Sciences Public and Occupational Health Enzyme-Linked Immunoassays lcsh:Science Mammals Vaccines Immune System Proteins Multidisciplinary biology Foot-and-mouth disease Eukaryota Agriculture Ruminants 04 agricultural and veterinary sciences Vaccination and Immunization Vaccination Infectious Diseases Veterinary Diseases Foot-and-Mouth Disease Virus Vertebrates Viral disease Antibody Research Article Livestock Infectious Disease Control 040301 veterinary sciences Immunology Foot and Mouth Disease Heterologous Research and Analysis Methods Antibodies 03 medical and health sciences Antigen medicine Animals Immunoassays Sheep lcsh:R Organisms Biology and Life Sciences Proteins Outbreak Viral Vaccines medicine.disease Virology 030104 developmental biology Foot-and-Mouth Disease Amniotes Immunologic Techniques biology.protein Veterinary Science lcsh:Q Preventive Medicine Zoology |
| Zdroj: | PLoS ONE, Vol 13, Iss 6, p e0195302 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Foot-and-mouth disease (FMD) is an acute, highly contagious viral disease of domestic and wild cloven-hoofed animals, caused by FMD virus (FMDV). An FMD outbreak can cause major production losses and have significant implications for trade. Vaccination can assist in controlling the disease, and emergency vaccination using high antigen payload vaccines (>6 PD50/dose) is considered an important control approach in the event of an outbreak. In recent years there has been a divergence of serotype A viruses in South East Asia (SEA) into several distinct genetic and antigenic clusters. Numerous variants were found to poorly match serotype A vaccines commonly included in international antigen banks. This study examined the ability of single vaccination with high-potency monovalent A22 IRQ vaccine to protect sheep following challenge with the A/VIT/15/2012 strain, just four days following vaccination. The vaccine proved effective at limiting clinical disease but did not prevent infection. |
| Databáze: | OpenAIRE |
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