Non-amnestic mild cognitive impairment and sleep complaints: a bidirectional relationship?

Autor: Marina Zanetti, Alessandro Padovani, Maddalena Riva, Anna Ceraso, Marta Conti, Salvatore Caratozzolo, Luca Rozzini
Rok vydání: 2017
Předmět:
Alzheimer disease
Daytime sleepiness
Dementia
Mild cognitive impairment
Neuropsychological characteristics
Sleep disorders
Male
Sleep Wake Disorders
Aging
medicine.medical_specialty
Neuropsychological Tests
Audiology
behavioral disciplines and activities
Developmental psychology
Pittsburgh Sleep Quality Index
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
mental disorders
medicine
Humans
Cognitive Dysfunction
030212 general & internal medicine
Cognitive decline
Depression (differential diagnoses)
Aged
Aged
80 and over
Depression
business.industry
Epworth Sleepiness Scale
Neuropsychology
medicine.disease
nervous system diseases
Case-Control Studies
Anxiety
Female
Self Report
Geriatrics and Gerontology
Alzheimer's disease
medicine.symptom
Cognition Disorders
Sleep
business
030217 neurology & neurosurgery
Zdroj: Aging Clinical and Experimental Research. 30:661-668
ISSN: 1720-8319
DOI: 10.1007/s40520-017-0814-8
Popis: Prior studies documented that several sleep disorders may coexist in patients affected by Mild Cognitive Impairment (MCI) and Alzheimer disease (AD), and have a strong bidirectional relationship with cognitive decline. To assess the self-reported sleep quality and daytime sleepiness among subjects affected by MCI and AD at early-stage and healthy controls, and to verify if sleep disturbances might be an indicator of specific cognitive deficits. 139 patients (102 MCI, 37 AD) underwent comprehensive neuropsychological, functional, and behavioral assessment, which also included Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). 80 healthy elderly subjects were used as controls. MCI patients have been divided into Good Sleepers and Bad Sleepers, depending on their reported sleep quality (PSQI global score ≤5/>5). MCI patients experienced more subjective daytime sleepiness than AD matches. As for the subjective sleep quality among MCI patients, 54% of Bad Sleepers met diagnostic criteria for non-amnestic MCI; vice-versa, 73% of Good Sleepers were diagnosed with amnestic-MCI (p = 0.005), independently of depression and anxiety. MCI patients complain of daytime sleepiness and dysfunction more than AD patients; among MCI patients, Bad Sleepers appear mainly characterized by a non-amnestic cognitive profile.
Databáze: OpenAIRE
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