Patients with HIV and cirrhosis: the risk for hepatocellular carcinoma after direct-acting antivirals for hepatitis C virus
| Autor: | Alice Toschi, Eleonora Salsi, Gabriella Verucchi, Gabriele Fabbri, Laura Sighinolfi, Francesco Cristini, Viola Guardigni, Gianluca Cuomo, Lorenzo Badia, Pierluigi Viale, Marco Massari, Elena Rosselli Del Turco |
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| Přispěvatelé: | Guardigni V., Toschi A., Badia L., Rosselli Del Turco E., Salsi E., Cristini F., Sighinolfi L., Fabbri G., Massari M., Cuomo G., Viale P., Verucchi G. |
| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Sustained Virologic Response Liver Cirrhosi Hepatitis C virus antiretroviral therapy Immunology Population Human immunodeficiency virus (HIV) HIV Infections Hepacivirus medicine.disease_cause Antiviral Agents Gastroenterology Retrospective Studie Internal medicine Genotype medicine Humans hepatitis C viru Immunology and Allergy HIV Infection education neoplasms Retrospective Studies Antiviral Agent direct-acting antiviral education.field_of_study Hepaciviru business.industry Liver Neoplasms HIV Cancer hepatocellular carcinoma Hepatitis C Chronic medicine.disease Hepatitis C digestive system diseases Infectious Diseases Hepatocellular carcinoma business Liver cancer cirrhosi Human |
| Zdroj: | AIDS. 35:1967-1972 |
| ISSN: | 1473-5571 0269-9370 |
| Popis: | OBJECTIVES: Hepatocellular carcinoma (HCC) has become a major issue in coinfected HIV/HCV patients with liver cirrhosis. We aimed to determine the rate of HCC occurrence after a direct-acting antiviral (DAA) treatment and to evaluate the factors associated with the risk of HCC in this population. DESIGN: We conducted a retrospective multicenter observational study including cirrhotic HIV/HCV-coinfected patients treated with DAAs, between October 2014 and January 2017. METHODS: We collected demographics characteristics, data regarding HIV and HCV infections and treatment with DAAs. We investigated the rate and the time of occurrence of HCC. Statistical analysis explored the factors associated to development of liver cancer. RESULTS: During a median follow-up of 55 months, 24 out of 232 patients developed HCC, after a median of 22.5 months from starting DAAs. Factors associated with HCC were a higher Child--Pugh Turcotte (CPT) score (P = 0.002), HCV genotype 3 (P = 0.04), previous HCC (P |
| Databáze: | OpenAIRE |
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