Naringin suppress chondrosarcoma migration through inhibition vascular adhesion molecule-1 expression by modulating miR-126
| Autor: | Tzu-Wei Tan, Chin-Jung Hsu, Wei-Hung Yang, Ying-Erh Chou, Yi-Chin Fong, Chih-Hsin Tang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
Citrus Stereochemistry Immunology Cell Chondrosarcoma Vascular Cell Adhesion Molecule-1 Motility Antineoplastic Agents Apoptosis Bone Neoplasms Metastasis chemistry.chemical_compound Cell Movement Cell Line Tumor medicine Humans Immunology and Allergy Neoplasm Invasiveness Molecular Targeted Therapy Cell adhesion Naringin Pharmacology Chemistry musculoskeletal system medicine.disease Gene Expression Regulation Neoplastic MicroRNAs medicine.anatomical_structure Fruit Flavanones Cancer research Immunoglobulin superfamily |
| Zdroj: | International Immunopharmacology. 22:107-114 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2014.06.029 |
| Popis: | Chondrosarcoma, a primary malignant bone cancer, has a potent capacity to invade locally and cause distant metastasis, especially to the lungs. Patients diagnosed with it have poor prognosis. Naringin, polymethoxylated flavonoid commonly found in citrus fruits, has anti-oxidant, anti-inflammatory and anti-tumor activity; whether naringin regulates migration of chondrosarcoma is largely unknown. Here we report that naringin does not expedite apoptosis in human chondrosarcoma. By contrast, at noncytotoxic concentrations, naringin suppressed migration and invasion of chondrosarcoma cells. Vascular cell adhesion molecule-1 (VCAM-1) of the immunoglobulin superfamily is linked with metastasis; we found incubation of chondrosarcoma cells with naringin reducing mRNA transcription for, and cell surface expression of, VCAM-1. We also observed that naringin enhancing miR-126 expression, and miR-126 inhibitor reversed the naringin-inhibited cell motility and VCAM-1 expression. Therefore, naringin inhibits migration and invasion of human chondrosarcoma via down-regulation of VCAM-1 by increasing miR-126. Thus, naringin may be a novel anti-migration agent for the treatment of migration in chondrosarcoma. |
| Databáze: | OpenAIRE |
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