Predictive Impact of the Inducibility of Ventricular Fibrillation in Patients With Brugada-Type ECG
Autor: | Shoji Hirasawa, Hidehira Fukaya, Masaru Yuge, Takeshi Sasaki, Tohru Izumi, Shinichi Niwano, Sae Sasaki, Masahiko Moriguchi, Ryuta Imaki, Daisuke Sato |
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Rok vydání: | 2006 |
Předmět: |
Male
medicine.medical_specialty Bundle-Branch Block Coronary Angiography Asymptomatic Sudden death Group B Iodine Radioisotopes Electrocardiography Predictive Value of Tests Internal medicine medicine Humans Radionuclide Imaging Brugada syndrome medicine.diagnostic_test business.industry Coronary Stenosis Heart Syndrome General Medicine Middle Aged Prognosis medicine.disease Acetylcholine Electrophysiology 3-Iodobenzylguanidine Predictive value of tests Ventricular Fibrillation Ventricular fibrillation Cardiology Population study Female Radiopharmaceuticals medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies |
Zdroj: | International Heart Journal. 47:229-236 |
ISSN: | 1349-3299 1349-2365 |
DOI: | 10.1536/ihj.47.229 |
Popis: | The natural history of asymptomatic individuals with a Brugada-type electrocardiogram (ECG) is still controversial. In this study, we evaluated ventricular fibrillation (VF) inducibility in Brugada-type ECG patients and compared it with other risk factors to clarify the significance of these data on their prognosis. The study population consisted of 38 patients who presented with a typical ST-segment elevation in the precordial leads and underwent an electrophysiological study (EPS). The patients were divided into 3 groups; group A: patients with spontaneous ventricular fibrillation (VF) (n = 5), group B: patients without clinical VF but with inducible VF in EPS (n = 16), and group C: patients with neither clinical nor inducible VF (n = 17). The clinical features, diagnostic results, and prognosis were compared among these groups. During the follow-up period of 26 +/- 19 months, 2/5 (group A), 1/16 (group B), and 0/17 (group C) patients suffered fatal arrhythmic events. None of the clinical features showed any significant difference, although the incidence of positive results in a drug challenge test was higher in groups A and B than in group C (P < 0.05). On the other hand, VF inducibility was higher in patients with positive results in the drug challenge test than in patients with negative results (59% versus 13%; P < 0.05). No VF episodes were observed in patients without VF induction, although one was observed in 1 of 16 patients with VF induction in asymptomatic Brugada syndrome. The drug challenge test appears to be useful for predicting VF inducibility even though it is a noninvasive test. |
Databáze: | OpenAIRE |
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