Biological cost of fluoroquinolone resistance in Escherichia coli implicated in polyclonal infection

Autor:	C. Guitton, S. Corvec, C. Giraudeau, G. Le Gargasson, Pascale Bémer, H. Drugeon, E. Espaze
Rok vydání:	2006
Předmět:	Male Biology medicine.disease_cause Microbiology Fatal Outcome Drug Resistance Bacterial medicine Pulsed-field gel electrophoresis Humans Surgical Wound Infection Escherichia coli Escherichia coli Infections Antibacterial agent Mutation General Medicine biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses biology.organism_classification Enterobacteriaceae Kidney Transplantation Polyclonal antibodies biology.protein Kidney Failure Chronic Ofloxacin Bacteria medicine.drug Fluoroquinolones
Zdroj:	Pathologie-biologie. 55(6)
ISSN:	0369-8114
Popis:	Polyclonal Escherichia coli strains were isolated in a transplanted patient who experienced successive septic shocks. Fluoroquinolone susceptible and resistant strains were corresponding to different PFGE fragment profiles. The gyrA S83L mutation was associated with a reduction in biological fitness. Resistant strain was selected by a long-term single use of ofloxacin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d14c74a0937a558d16d6304978bc980 https://pubmed.ncbi.nlm.nih.gov/16884861 Zobrazit plný text záznamu Full Text from ScienceDirect