Mycobacterium tuberculosis Uses Mce Proteins to Interfere With Host Cell Signaling
| Autor: | Chi Tung Wong, Katherine Fenn, Vidya Chandran Darbari |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway integrin Mini Review Host–pathogen interaction Protein domain Integrin Mce protein host-pathogen interaction EF1A1 Biochemistry Genetics and Molecular Biology (miscellaneous) Biochemistry Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Inner membrane Molecular Biosciences lcsh:QH301-705.5 Molecular Biology biology Permease biology.organism_classification Eukaryotic translation elongation factor 1 alpha 1 3. Good health Cell biology ERK 030104 developmental biology lcsh:Biology (General) host cell signaling 030220 oncology & carcinogenesis biology.protein |
| Zdroj: | Frontiers in Molecular Biosciences, Vol 6 (2020) Frontiers in Molecular Biosciences |
| ISSN: | 2296-889X |
| DOI: | 10.3389/fmolb.2019.00149 |
| Popis: | Tuberculosis continues to be the main cause for mortality by an infectious agent, making Mycobacterium tuberculosis one of the most successful pathogens to survive for long durations within human cells. In order to survive against host defenses, M. tuberculosis modulates host cell signaling. It employs many proteins to achieve this and the Mce proteins are emerging as one group that play a role in host cell signaling in addition to their primary role as lipid/sterol transporters. Mce proteins belong to the conserved Mce/MlaD superfamily ubiquitous in diderm bacteria and chloroplasts. In mycobacteria, mce operons, encode for six different Mce proteins that assemble with inner membrane permeases into complexes that span across the mycobacterial cell wall. Their involvement in signaling modulation is varied and they have been shown to bind ERK1/2 to alter host cytokine expression; eEF1A1 to promote host cell proliferation and integrins for host cell adherence and entry. Recently, structures of prokaryotic Mce/MlaD proteins have been determined, giving an insight into the conserved domain. In this mini-review, we discuss current evidence for the role of mycobacterial Mce proteins in host cell signaling and structural characteristics of the protein-protein interactions coordinated by the human proteins to modulate the host signaling. |
| Databáze: | OpenAIRE |
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