Ribosides and Ribotide of a Fairy Chemical, Imidazole-4-carboxamide, as Its Metabolites in Rice
| Autor: | Makoto Inai, Jing Wu, Nobuo Matsuzaki, Mihaya Kotajima, Mitsuru Kondo, Tomohiro Asakawa, Hirofumi Hirai, Hitoshi Ouchi, Toshiyuki Kan, Jae-Hoon Choi, Hirokazu Kawagishi |
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| Rok vydání: | 2019 |
| Předmět: |
Models
Molecular Ribonucleotide Molecular Structure 010405 organic chemistry Stereochemistry medicine.drug_class Chemistry Organic Chemistry food and beverages Carboxamide Biological activity Oryza Metabolism Ribonucleotides 010402 general chemistry Aminoimidazole Carboxamide 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound cardiovascular system medicine Imidazole Ribonucleosides Physical and Theoretical Chemistry |
| Zdroj: | Organic letters. 21(19) |
| ISSN: | 1523-7052 |
| Popis: | The metabolism of imidazole-4-carboxamide (ICA) in plants has been unknown. Two metabolites (1 and 2) were isolated from ICA-treated rice, and their structures were determined by spectroscopic analysis including the single-crystal X-ray diffraction technique and synthesis. The ribotide of ICA (3), whose existence was predicted, was also synthesized and detected from the treated rice by LC-MS/MS. These results indicated that rice might interconvert ICA, 1, and 3 to regulate the biological activity. |
| Databáze: | OpenAIRE |
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