Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters
| Autor: | Yonggui Robin Chi, Jianfeng Xu, Jacqueline Zi Mei Fong, Song Yang, Yunpeng Lu, Baoan Song, Xingkuan Chen, Chengli Mou |
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| Přispěvatelé: | School of Physical and Mathematical Sciences |
| Rok vydání: | 2016 |
| Předmět: |
Carbene-catalyzed reactions
010405 organic chemistry General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Catalysis 0104 chemical sciences Kinetic resolution chemistry.chemical_compound Carboxylic esters Colloid and Surface Chemistry chemistry Yield (chemistry) Organic chemistry Carbene |
| Zdroj: | Journal of the American Chemical Society. 138:7212-7215 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.6b00406 |
| Popis: | Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Accepted version |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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