Parsing variability in borderline personality disorder: a meta-analysis of neuroimaging studies
| Autor: | Cristiano Fernandes da Costa, Giorgia Degasperi, Elisa Di Rosa, Claudio Gentili, Ioana A. Cristea |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Amygdala Brain Brain Mapping Emotions Humans Magnetic Resonance Imaging Neuroimaging Borderline Personality Disorder Brain activity and meditation Inferior frontal gyrus Neurosciences. Biological psychiatry. Neuropsychiatry Audiology Brain mapping behavioral disciplines and activities Article Cellular and Molecular Neuroscience mental disorders Human behaviour medicine Borderline personality disorder Biological Psychiatry medicine.diagnostic_test medicine.disease Psychiatry and Mental health medicine.anatomical_structure Psychology Functional magnetic resonance imaging Psychiatric disorders Insula RC321-571 Neuroscience |
| Zdroj: | Translational Psychiatry Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021) |
| Popis: | Though a plethora of functional magnetic resonance imaging (fMRI) studies explored the neurobiological underpinnings of borderline personality disorder (BPD), findings across different tasks were divergent. We conducted a systematic review and activation likelihood estimation (ALE) meta-analysis on the fMRI studies conducted in BPD patients compared to healthy controls (HC). We systematically searched PubMed and PsychINFO from inception until July 9th 2020 using combinations of database-specific terms like ‘fMRI’, ‘Neuroimaging’, ‘borderline’. Eligible studies employed task-based fMRI of the brain in participants of any age diagnosed with BPD compared to HC, during any behavioral task and providing a direct contrast between the groups. From 762 entries, we inspected 92 reports full-texts and included 52 studies (describing 54 experiments). Across all experiments, the HC > BPD and BPD > HC meta-analyses did not yield any cluster of significant convergence of differences. Analyses restricted to studies of emotion processing revealed two significant clusters of activation in the bilateral hippocampal/amygdala complex and anterior cingulate for the BPD > HC meta-analysis. Fail-safe N and single study sensitivity analysis suggested significant findings were not robust. For the subgroup of emotional processing experiments, on a restricted number of experiments providing results for each group separately, another meta-analysis method (difference of convergence) showed a significant cluster in the insula/inferior frontal gyrus for the HC > BPD contrast. No consistent pattern of alteration in brain activity for BPD was evidenced suggesting substantial heterogeneity of processes and populations studied. A pattern of amygdala dysfunction emerged across emotion processing tasks, indicating a potential pathophysiological mechanism that could be transdiagnostic. |
| Databáze: | OpenAIRE |
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