IL-2 and TNF-α Promoter Polymorphisms in Patients With Acute Kidney Graft Rejection
| Autor: | Andrzej Pawlik, M Florczak, Barbara Gawrońska-Szklarz, Grażyna Dutkiewicz, Jacek Różański, Leszek Domański, Ewa Dabrowska-Zamojcin |
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| Rok vydání: | 2005 |
| Předmět: |
Graft Rejection
Genotype Urinary system medicine.medical_treatment Proinflammatory cytokine Pathogenesis medicine Humans Promoter Regions Genetic Sequence Deletion Transplantation Kidney Polymorphism Genetic Tumor Necrosis Factor-alpha business.industry Genetic Carrier Screening Graft Survival Homozygote Interleukin Kidney Transplantation surgical procedures operative medicine.anatomical_structure Cytokine Acute Disease Immunology Interleukin-2 Surgery Tumor necrosis factor alpha business Polymorphism Restriction Fragment Length |
| Zdroj: | Transplantation Proceedings. 37:2041-2043 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2005.03.091 |
| Popis: | Proinflammatory cytokines have been implicated in the pathogenesis of acute kidney allograft rejection. The aim of the study was to examine the association between interleukin (IL)-2 -330 and tumor necrosis factor (TNF)-alpha -308 promoter polymorphisms and acute kidney allograft rejection.The study included 72 patients with long-term stable graft function, and 57 diagnosed with acute kidney allograft rejection.Patients with acute kidney allograft rejection showed a prevalence of subjects with TNF-alpha T2 allele (P.05). The risk of acute kidney allograft rejection diagnosis was 2.5-fold greater among carriers of the T2 allele than those homozygous for T1T1 (OR 2.53, 95% CI 1.19 to 5.37, P.05) There was no statistically significant difference in the distribution of IL-2 genotypes between patients with stable graft function and acute kidney allograft rejection.The results suggest that TNF-alpha-308 promoter polymorphism is a risk factor for acute kidney allograft rejection. |
| Databáze: | OpenAIRE |
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