Early detection of sporadic pancreatic cancer
| Autor: | Pavel Škrha, Jan Škrha, Miroslav Zavoral, Přemysl Frič, Petr Busek, Martin Laclav, Aleksi Sedo |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Time Factors Diagnostic methods Early detection Disease Malignancy Risk Assessment 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Pancreatic cancer medicine Humans Early Detection of Cancer Hepatology business.industry Gastroenterology Prognosis medicine.disease Pancreatic Neoplasms 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business Carcinoma Pancreatic Ductal |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 29:885-891 |
| ISSN: | 0954-691X |
| DOI: | 10.1097/meg.0000000000000904 |
| Popis: | Sporadic pancreatic cancer amounts to ∼90% of all pancreatic cancers. It is a gloomy depressive disease and the most recalcitrant malignancy, with a very low 5-year survival (3-6%). At present, diagnostic methods are commonly applied, as used half a century ago, after the appearance of local and systemic symptoms (abdominal and back pain, cholestasis, painless jaundice, fatigue, anorexia, weight loss, anemia, peripheral phlebitis, and cachexia). Unfortunately, these symptoms are harbingers of an advanced disease. The subsequent imaging methods may offer additional information on the location, size, and morphology of the lesion, but they do not influence the prognosis. Radical surgery may be offered to 15-20% of patients. The relapses after surgery are frequent and chemotherapy may be palliative. Preventive programs represent the only possibility of improvement. We propose the first multistep and multidisciplinary preventive program for early detection of sporadic pancreatic cancer for the differential identification of average-risk patients who probably have the disease from those who do not. |
| Databáze: | OpenAIRE |
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