Volumetric hand-held optoacoustic angiography as a tool for real-time screening of dense breast
| Autor: | X. Luís Deán-Ben, Daniel Razansky, Thomas Felix Fehm, Monika Gostic |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Breast imaging General Physics and Astronomy Breast Neoplasms Signal-To-Noise Ratio 01 natural sciences General Biochemistry Genetics and Molecular Biology 030218 nuclear medicine & medical imaging Photoacoustic Techniques 010309 optics 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine 0103 physical sciences medicine Humans Mass Screening Mammography General Materials Science Breast Breast tissue medicine.diagnostic_test business.industry Hand held Ultrasound Angiography General Engineering Magnetic resonance imaging General Chemistry Female Radiology Tomography business |
| Zdroj: | Journal of Biophotonics. 9:253-259 |
| ISSN: | 1864-063X |
| Popis: | Existing mammographic screening solutions are generally associated with several major drawbacks, such as exposure to ionizing radiation or insufficient sensitivity in younger populations with radiographically-dense breast. Even when combined with ultrasound or magnetic resonance imaging, X-Ray mammography may still attain unspecific or false positive results. Thus, development of new breast imaging tools represents a timely medical challenge. We report on a new approach to high-resolution functional and anatomical breast angiography using volumetric hand-held optoacoustic tomography, which employs light intensities safe for human use. Experiments in young healthy volunteers with fibroglandular-dominated dense breasts revealed the feasibility of rendering three-dimensional images representing vascular anatomy and functional blood oxygenation parameters at video rate. Sufficient contrast was achieved at depths beyond 2 cm within dense breasts without compromising the real-time imaging performance. The suggested solution may thus find applicability as a standalone or supplemental screening tool for early detection and follow-up of carcinomas in radiographically-dense breasts. Volumetric handheld optoacoustic tomography scanner uses safe pulses of near-infrared light to render three-dimensional images of deep vascular anatomy, blood oxygenation and breast parenchyma at video rate. |
| Databáze: | OpenAIRE |
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