Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation
| Autor: | Tetsuo Tanaka, Minako Uenohara, Satoru Suehara, Takuya Nishikawa, Masaru Sugimachi, Satoshi Sawada, Yohsuke Hayama, Toru Kawada |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Physiology Urination Diuresis Blood Pressure Baroreflex Kidney Rats Inbred WKY Internal medicine Animals Medicine Arterial Pressure Urine output Denervation business.industry Carotid sinus Sympathetic nerve activity Rats Blood pressure medicine.anatomical_structure Cardiology business Urine flow |
| Zdroj: | The Journal of Physiological Sciences. 70 |
| ISSN: | 1880-6562 1880-6546 |
| Popis: | Primary acute sympathetic activation (PASA) can increase arterial pressure (AP). Under this situation, the kidneys may receive mutually opposing influences from sympathetic activation: a direct anti-diuretic effect via the renal innervation and pressure diuresis. We examined whether PASA would reduce urine output regardless of the AP elevation. We also examined the impact of renal denervation (RDN) on urine output during PASA. The experiment was performed on rats 3 to 9 days after unilateral RDN (n = 10). Under anesthesia, systemic sympathetic nerve activity (SNA) was varied over a wide range via the carotid sinus baroreflex. The slope of urine flow versus SNA was positive (0.252 ± 0.052 μL·min−1·kg−1· %−1) on the intact side, and it was greater on the denervated side (0.331 ± 0.069 μL·min−1·kg−1· %−1, P |
| Databáze: | OpenAIRE |
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