The Contribution of Four Immunogenetic Markers for Predicting Persistent Activity in Patients with Recent-Onset Rheumatoid Arthritis or Undifferentiated Arthritis
| Autor: | Alicia García, Luis Pestana, María Francisca González-Escribano, Sonsoles Reneses, Antonio Fernández-Suárez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Article Subject business.industry Area under the curve Logistic regression medicine.disease Gastroenterology Undifferentiated arthritis Internal medicine Rheumatoid arthritis Cohort Immunology Linear regression medicine Rheumatoid factor In patient business skin and connective tissue diseases Research Article |
| Zdroj: | ISRN Rheumatology |
| ISSN: | 2090-5467 |
| DOI: | 10.5402/2011/780356 |
| Popis: | We assessed the contribution of four baseline markers—HLA-DRB1 shared epitope (SE), −308 tumor necrosis factor α gene promoter polymorphism, rheumatoid factor, and anticitrullinated peptide antibodies—for predicting persistent activity (DAS28 score ≥2.6) after one year of followup in a cohort of 201 patients with recent-onset rheumatoid arthritis (RA) or undifferentiated arthritis (UA) aged 16 years or older who had a 4-week to 12-month history of swelling of at least two joints. Patients had not been previously treated with corticosteroids or disease-modifying antirheumatic drugs (DMARD). In the best logistic regression model, only two variables were retained: SE positivity and number of DMARD administered (area under the curve = 76.4%; 95% CI: 69.2%, 84.4%; ). The best linear regression model also included these two variables, explaining only 22.5% of the variability of DAS28 score. In this study, given an equal number of DMARD administered, the probability of persistent activity in patients with recent-onset RA or UA was significantly influenced by SE presence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|