Complement Factor H and Complement Factor H-Related Protein 5 Mutations Associated with Atypical Hemolytic Uremic Syndrome in a Systemic Lupus Erythematosus Patient: Efficacy of Eculizumab

Autor: Bengü Erkul, Sibel Ersan, Semih Gülle, Zevcet Yilmaz, Banu Avcioglu Yilmaz
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Popis: Atypical hemolytic uremic syndrome (aHUS) is a disorder characterized by a propensity to thrombotic microangiopathy (TMA) due to defective regulation of the alternative complement pathway. Mutations in genes encoding complement factor H (CFH) and complement factor H-related proteins (CH IR) can be related with aHUS and identified in patients with rheumatologic diseases.
Databáze: OpenAIRE