Autoimmune polyendocrinopathy
| Autor: | William Rojas García, Mariana Barrera Valencia |
|---|---|
| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2020 |
| Předmět: |
vitiligo
Medicine (General) Economics and Econometrics medicine.medical_specialty Diabetic ketoacidosis síndrome poliglandular autoinmune autoimmune polyendocrinopathy Autoimmune Gastritis autoimmune polyglandular syndrome Vitiligo R5-920 Materials Chemistry Media Technology Medicine pernicious anemia business.industry Insulin glargine endocrinopatía múltiple autoinmune hipotiroidismo autoinmune Autoantibody Forestry Autoimmune polyendocrinopathy Alopecia areata medicine.disease Dermatology type 1diabetes autoimmune hypothyroidism diabetes tipo 1 business medicine.drug |
| Zdroj: | Repositorio Digital Institucional ReDi Fundación Universitaria de Ciencias de la Salud-FUCS instacron:Fundación Universitaria de Ciencias de la Salud-FUCS Repertorio de Medicina y Cirugía, Vol 29, Iss 2 (2020) |
| Popis: | Autoantibodies are blood proteins produced in response to and counteracting a specific antigen. Autoantibodies may be present before signs and symptoms occur. A polyendocrinopathy is characterized by the coexistence of at least two endocrine glands insufficiency and may be associated with another non-endocrine autoimmune illness including vitiligo, alopecia areata, autoimmune gastritis and pernicious anemia. It is classified into three types of autoimmune polyglandular syndromes (APS). In Europe the incidence of APS-1 is less than one new case per 100000 persons per year and the incidence of the other two APS types vary between1 to 2 new cases per 100000 persons per year. APS incidence in Colombia cannot be estimated due to lack of records on this subject. We report the case of an 18-year-old male with autoimmune hypothyroidism diagnosed at 15 years of age, with onset of diabetic ketoacidosis at 17 followed by vitiligo. Therapy with levothyroxine 100 mcg daily and insulin glargine 10 units daily did not yield successful correction of APS in the patient. This patient was affected by APS- IIIA, characterized by the association of autoimmune hypothyroidism, diabetes mellitus and vitiligo, as the last manifestation. Detecting an autoimmune polyendocrinopathy in young patients should raise the suspicion of APS |
| Databáze: | OpenAIRE |
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