Generation, sampling, and analysis for low-level GB (Sarin) and GF (Cyclosarin) vapor for inhalation toxicology studies

Autor:	Kathy L. Matson, Sandra A. Thomson, William T. Muse, Charles L. Crouse
Rok vydání:	2006
Předmět:	Syringe Drive Sarin Inhalation Exposure Chromatography Threshold limit value Health Toxicology and Mutagenesis Nebulizers and Vaporizers Cyclosarin Inhalation Toxicology Toxicology Inhalation chamber chemistry.chemical_compound Organophosphorus Compounds chemistry Environmental chemistry medicine Cholinesterase Inhibitors Volatilization Spray atomization Nerve agent medicine.drug
Zdroj:	Inhalation toxicology. 18(14)
ISSN:	1091-7691
Popis:	This study tested and optimized various methodologies to generate, sample, and characterize GB and GF test atmospheres in an inhalation chamber, particularly at low vapor levels. A syringe drive/spray atomization system produced vapor concentrations at a range of 1–50 mg/m3. A saturator cell was used to generate vapor at sub-lethal concentrations ranging from 1 mg/m3 down to low levels approaching the threshold limit value time-weighted average (TLV-TWA) of 0.0001 mg/m3 for GB. Both generation techniques demonstrated the ability to produce stable vapor concentrations over extended exposure periods. This capability was important to determine sublethal nerve agent effects, such as miosis, for inhalation toxicology studies. In addition, the techniques employed for producing and maintaining low-level agent vapor would lay the foundation for testing less volatile chemical warfare agents such as VX.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d079e201e750ed660e372b000f646f8 https://pubmed.ncbi.nlm.nih.gov/17050347 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.