Diagnostic adequacy and safety of endoscopic ultrasound-guided fine-needle aspiration in patients with lymphadenopathy in a large cohort
| Autor: | Narendra S. Choudhary, Haimanti Sarin, Rinkesh Kumar Bansal, Rajesh Puri, Mahesh Kumar Gupta, Chitranshu Vashishtha, Gagandeep Kaur, Saurabh K. Patle |
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| Rok vydání: | 2018 |
| Předmět: |
Endoscopic ultrasound
Original article medicine.medical_specialty medicine.diagnostic_test business.industry medicine.disease Chronic liver disease Malignancy 03 medical and health sciences 0302 clinical medicine Fine-needle aspiration 030220 oncology & carcinogenesis Cohort medicine Etiology lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology Pharmacology (medical) Radiology Lymph lcsh:RC799-869 business Hepatic encephalopathy |
| Zdroj: | Endoscopy International Open Endoscopy International Open, Vol 06, Iss 04, Pp E421-E424 (2018) |
| ISSN: | 2196-9736 2364-3722 |
| DOI: | 10.1055/s-0043-121986 |
| Popis: | Background and study aims The role of endoscopic-ultrasound (EUS) guided fine-needle aspiration (FNA) in patients with lymphadenopathy in terms of diagnostic adequacy and safety in large population is not well defined. The aim of this study was to evaluate diagnostic adequacy and safety of EUS-FNA in patients with lymphadenopathy. Patients and methods Retrospective study from October 2010 to September 2015 at tertiary care center in Delhi-NCR. We analyzed data from 1005 EUS- FNAs of lymph nodes. Results The study cohort comprised 1005 lymph nodes in 865 patients; 68 % were males, mean age was 50 ± 14 years. Indications of FNA were to look for etiology of pyrexia of unknown origin or staging of malignancy mainly. FNA was taken from mediastinal nodes (n = 528, 52.5 %) and intra-abdominal nodes (n = 477, 47.5 %). Median size of nodes at long axis and short axis was 17 (12 – 25.7) and 10 (8 – 15) mm respectively. Adequate material by FNA was obtained in 92.8 % cases. The cytopathologic diagnosis were malignancy in 153 (15.2 %), granulomatous change in 452 (42 %), and reactive lymphadenopathy in 328 (35.6 %). There was statistically significant difference seen between groups with pathological and reactive lymph nodes regarding size at long and short axis, hypoechoic nature, well defined borders and presence of necrosis and calcification. Procedure-related adverse effects were encountered in 6 patients (0.8 %). Four patients had mild mucosal bleeding in chronic liver disease patients and two had mild hepatic encephalopathy related to sedation. Conclusion EUS-FNA of lymph nodes has good diagnostic adequacy and safety. |
| Databáze: | OpenAIRE |
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