The chemotherapy of rodent malaria, XXVII Studies on mefloquine (WR 142,490)
| Autor: | R. E. Howells, W. Peters, J. H. Portus, David C. Warhurst, B. L. Robinson, S. C. Thomas |
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| Rok vydání: | 1977 |
| Předmět: |
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Bacterial Primaquine Plasmodium berghei 030231 tropical medicine Pharmacology Antimalarials Mice 03 medical and health sciences 0302 clinical medicine Piperidines In vivo Chloroquine 030225 pediatrics parasitic diseases medicine Animals Drug Interactions Quinine Dose-Response Relationship Drug biology Pigmentation Mefloquine Chemistry Drug Resistance Microbial Drug Synergism biology.organism_classification medicine.disease Malaria Drug Combinations Infectious Diseases Pyrimethamine Quinolines Parasitology medicine.drug |
| Zdroj: | Annals of Tropical Medicine & Parasitology. 71:407-418 |
| ISSN: | 1364-8594 0003-4983 |
| Popis: | Mefloquine (WR 142,490) is a potent blood schizontocide active against drug-sensitive and drug-resistant lines of Plasmodium berghei. The ED50 and ED90 against the P. berghei N strain in albino mice are 1.5 and 3.8 mg/kg respectively. The highly chloroquine-resistant RC line is less sensitive and mefloquine is not fully effective at the maximum tolerated dose in the '4-day test'. Mefloquine has a similar mode of action to quinine both in vitro and (as demonstrated by the morphological changes it induces in P. berghei) in vivo, but is some 100 times more potent. Unlike quinine and WR 122,455 it appears not to interact with DNA. It has no causal prophylactic effect. Mixtures of mefloquine with pyrimethamine, sulphaphenazole or primaquine have an additive effect. |
| Databáze: | OpenAIRE |
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