What women want: Fertility sparing surgery in Borderline ovarian tumours patients and pregnancy outcome

Autor: Michele Peiretti, Giorgio Candotti, Raffaella Cioffi, Giorgia Mangili, Massimo Candiani, Luca Bocciolone, Valerio Mais, Emanuela Rabaiotti, Alice Bergamini
Přispěvatelé: Candotti, G., Peiretti, M., Mangili, G., Bergamini, A., Candiani, M., Cioffi, R., Mais, V., Rabaiotti, E., Bocciolone, L.
Rok vydání: 2020
Předmět:
Adult
medicine.medical_specialty
Pregnancy Rate
Reproductive Techniques
Assisted
media_common.quotation_subject
medicine.medical_treatment
Salpingo-oophorectomy
Fertility
Carcinoma
Ovarian Epithelial
Pregnancy outcome
Fertility sparing surgery
Cystectomy
03 medical and health sciences
0302 clinical medicine
Pregnancy
Humans
Medicine
Nuclear atypia
Ovarian tumours
Retrospective Studies
media_common
Ovarian Neoplasms
030219 obstetrics & reproductive medicine
Cesarean Section
business.industry
Obstetrics
Age Factors
Pregnancy Outcome
Fertility Preservation
Borderline ovarian tumour
General Medicine
Delivery
Obstetric
medicine.disease
Adenocarcinoma
Mucinous
Pregnancy rate
Italy
Oncology
030220 oncology & carcinogenesis
Female
Surgery
Neoplasm Recurrence
Local
Neoplasms
Cystic
Mucinous
and Serous
business
Live birth
Organ Sparing Treatments
Zdroj: European Journal of Surgical Oncology. 46:888-892
ISSN: 0748-7983
DOI: 10.1016/j.ejso.2019.11.001
Popis: Objective Borderline ovarian tumours (BOTs) are characterized by the presence of cellular proliferation and nuclear atypia without stromal invasion. Compared to malignant ovarian tumours, BOTs have better prognoses. The most important treatment of BOT is surgery. Considering the good prognosis of BOT, fertility-sparing surgery (FSS) can be considered for young women who desire to preserve fertility. Our study evaluated the pregnancy rate in patients with childbearing desire, the efficacy and risk of recurrence of women affected by BOTs who have undergone FSS. Materials and methods Patients characteristics have been restrospectively retrieved for diagnosis made from June 2000 to December 2017 from San Raffaele Hospital and Policlinico Cagliari. Patients underwent FSS for BOT were interviewed about child wishing and pregnancy outcomes. Results 85 patients were recruited for the study. Median age at diagnosis was 33 years. Unilateral salpingo-oophorectomy was performed in 33 patients (38%), unilateral cystectomy in 40 (47%) and 12 underwent both procedures (14%). 40 women (50%) tried to conceive after surgery. The pregnancy rate was 73% and live birth rate was 67%. Childbearing desire and age at diagnosis were significantly associated with the pregnancy rate. Conclusions Conservative surgical treatment seems to be a reasonable therapeutic option for women with BOTs who wish to preserve fertility. Our results suggest that the obstetric outcomes after FSS are promising. Maternal desire and the age of diagnosis are the most important factors affecting PR after surgery. Fertility counselling should be an integral part of the clinical management of women with BOT.
Databáze: OpenAIRE
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