Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?

Autor:	Nadim Hourani, Hande Karaköse, Sagar Deshpande, Marius Febi Matei, Nikolai Kuhnert, Farnoosh Dairpoosh, Agnieszka Golon, Rakesh Jaiswal, Hany F. Nour
Rok vydání:	2010
Předmět:	chemistry.chemical_classification biology Allosteric regulation Biophysics food and beverages Biological activity Enzyme Interaction Cell Biology Biochemistry Dietary Polyphenol Enzyme inhibition Enzyme chemistry Allosteric enzyme Polyphenol biology.protein Original Article
Zdroj:	Journal of chemical biology. 4(3)
ISSN:	1864-6166
Popis:	Inspired by a recent article by Prinz, suggesting that Hill coefficients, obtained from four parameter logistic fits to dose–response curves, represent a parameter allowing distinction between a general allosteric denaturing process and real single site enzyme inhibition, Hill coefficients of a number of selected dietary polyphenol enzyme inhibitions were compiled from the available literature. From available literature data, it is apparent that the majority of polyphenol enzyme interactions reported lead to enzyme inhibition via allosteric denaturing rather than single site inhibition as judged by their reported Hill coefficients. The results of these searches are presented and their implications discussed leading to the suggestion of a novel hypothesis for polyphenol biological activity termed the insect swarm hypothesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d02c821f7d91428fda7e69b113f49da https://pubmed.ncbi.nlm.nih.gov/22287993 Zobrazit plný text záznamu Full text from SpringerLink