Population-Based Risk Factors for Ascending, Arch, Descending, and Abdominal Aortic Dilations for 60-74–Year-Old Individuals
| Autor: | Flemming Hald Steffensen, Marek Karon, Lasse M. Obel, Kenneth Egstrup, Lars Frost, Oke Gerke, Martin Busk, Jes S. Lindholt, Grazina Urbonaviciene, Jess Lambrechtsen, Anders S. Bovling, Lars Melholt Rasmussen, Axel Cosmus Pyndt Diederichsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Denmark prevalence aortic dilations and aneurysms Aorta Thoracic Blood Pressure Aortography Risk Assessment Sex Factors Risk Factors Internal medicine Ectasia medicine.artery Humans Medicine risk factors Aorta Abdominal Myocardial infarction Risk factor abdominal and thoracic aorta Aged Body surface area Aorta Aortic Segment Aortic Aneurysm Thoracic business.industry Age Factors Odds ratio Middle Aged medicine.disease population-based Blood pressure Cardiology cardiovascular system Female epidemiology Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Aortic Aneurysm Abdominal |
| Zdroj: | Obel, L M, Diederichsen, A C, Steffensen, F H, Frost, L, Lambrechtsen, J, Busk, M, Urbonaviciene, G, Egstrup, K, Karon, M, Rasmussen, L M, Gerke, O, Bovling, A S & Lindholt, J S 2021, ' Population-Based Risk Factors for Ascending, Arch, Descending, and Abdominal Aortic Dilations for 60-74–Year-Old Individuals ', Journal of the American College of Cardiology, vol. 78, no. 3, pp. 201-211 . https://doi.org/10.1016/j.jacc.2021.04.094 |
| DOI: | 10.1016/j.jacc.2021.04.094 |
| Popis: | Background Aortic dilations (ectasias and aneurysms) may occur on any segment of the aorta. Pathogenesis varies between locations, suggesting that etiology and risk factors may differ. Despite this discrepancy, guidelines recommend screening of the whole aorta if 1 segmental dilation is discovered. Objectives The purpose of this study was to determine the most dominant predictors for dilations at the ascending, arch, descending, and abdominal part of the aorta, and to establish comprehensive risk factor profiles for each aortic segment. Methods Individuals aged 60-74 years were randomly selected to participate in DANCAVAS I+II (Danish Cardiovascular Multicenter Screening Trials). Participants underwent cardiovascular risk assessments, including blood samples, blood pressure readings, medical records, and noncontrast computed tomography scans. Adjusted odds ratios for potential risk factors of dilations were estimated by multivariate logistic analyses. Results The study population consisted of 14,989 participants (14,235 men, 754 women) with an average age of 68 ± 4 years. The highest adjusted odd ratios for having any aortic dilation were observed when coexisting aortic dilations were present. Other noteworthy predictors included coexisting iliac dilations, hypertension, increasing body surface area, male sex, familial disposition, and atrial fibrillation, which were present in various combinations for the different aortic parts. Smoking and acute myocardial infarction were inversely associated with ascending and abdominal dilations. Diabetes was a shared protective factor. Conclusions Risk factors differ for aortic dilations between locations. The most dominant predictor for having a dilation at any aortic segment is the presence of an aortic dilation elsewhere. This supports current guidelines when recommending a full screening of the aorta if a focal aortic dilation is discovered. |
| Databáze: | OpenAIRE |
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