Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality
| Autor: | Sina A. Gharib, Melanie Waldenberger, Janie Corley, Kurt Lohman, Roby Joehanes, Alice H. Lichtenstein, Antoine R Baldassari, Colleen M. Sitlani, Daniel Levy, Yongmei Liu, Trudy Voortman, Yinan Zheng, Jianto Ma, Alexis C. Wood, James S. Pankow, Eric A. Whitsel, Stella Aslibekyan, Steve Nguyen, W. David Hill, Lifang Hou, Ellen W. Demerath, Myriam Fornage, Casey M. Rebholz, Toshiko Tanaka, Ben Schöttker, Frank B. Hu, Carolina Ochoa-Rosales, Nona Sotoodehnia, Margit Heier, Emily A Hu, Michael M Mendelson, Annette Peters, Lindsay M. Reynolds, Maura E Walker, Mohamed A. Elhadad, Yan Zhang, Ian J. Deary, Kim V E Braun, Joyce B. J. van Meurs, Liming Liang, Jennifer A. Brody, Hermann Brenner, Tianxiao Huan, Rui Xia, André G. Uitterlinden, Niranjan G Biligowda, Mara Z. Vitolins, Elena Colicino, Shumao Ye, Chunyu Liu |
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| Přispěvatelé: | Epidemiology, Erasmus MC other, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Fatty Acid Desaturases
0301 basic medicine Physiology 030204 cardiovascular system & hematology Diet Mediterranean White People Body Mass Index 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Risk Factors Leukocytes Humans Medicine Triglycerides Whole blood business.industry Nuclear Proteins General Medicine Epigenome DNA Methylation 030104 developmental biology Diet quality Cardiovascular Disease Diet Dna Methylation Cardiovascular Diseases Suppressor of Cytokine Signaling 3 Protein DNA methylation Disease risk CpG Islands business All cause mortality Genome-Wide Association Study |
| Zdroj: | Ma, J, Rebholz, C M, Braun, K V E, Reynolds, L M, Aslibekyan, S, Xia, R, Biligowda, N G, Huan, T, Liu, C, Mendelson, M M, Joehanes, R, Hu, E A, Vitolins, M Z, Wood, A C, Lohman, K, Ochoa-Rosales, C, van Meurs, J B J, Andre Uitterlinden, A G, Liu, Y, Elhadad, M A, Heier, M, Waldenberger, M, Peters, A, Colicino, E, Whitsel, E A, Baldassari, A, Gharib, S A, Sotoodehnia, N, Brody, J A, Sitlani, C M, Tanaka, T, Hill, W D, Corley, J, Deary, I, Zhang, Y, Schöttker, B, Brenner, H, Walker, M E, Ye, S, Nguyen, S, Pankow, J, Demerath, E W, Zheng, Y, Hou, L, Liang, L, Lichtenstein, A H, Hu, F B, Fornage, M, Voortman, T & Levy, D 2020, ' Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality ', Circulation: Genomic and Precision Medicine . https://doi.org/10.1161/CIRCGEN.119.002766 Circ. Genom. Precis. Med. 13:e002766 (2020) Circulation. Genomic and precision medicine, 13(4). Lippincott Williams & Wilkins |
| ISSN: | 1942-325X |
| DOI: | 10.1161/CIRCGEN.119.002766 |
| Popis: | Background: DNA methylation patterns associated with habitual diet have not been well studied. Methods: Diet quality was characterized using a Mediterranean-style diet score and the Alternative Healthy Eating Index score. We conducted ethnicity-specific and trans-ethnic epigenome-wide association analyses for diet quality and leukocyte-derived DNA methylation at over 400 000 CpGs (cytosine-guanine dinucleotides) in 5 population-based cohorts including 6662 European ancestry, 2702 African ancestry, and 360 Hispanic ancestry participants. For diet-associated CpGs identified in epigenome-wide analyses, we conducted Mendelian randomization (MR) analysis to examine their relations to cardiovascular disease risk factors and examined their longitudinal associations with all-cause mortality. Results: We identified 30 CpGs associated with either Mediterranean-style diet score or Alternative Healthy Eating Index, or both, in European ancestry participants. Among these CpGs, 12 CpGs were significantly associated with all-cause mortality (Bonferroni corrected P −3 ). Hypermethylation of cg18181703 ( SOCS3 ) was associated with higher scores of both Mediterranean-style diet score and Alternative Healthy Eating Index and lower risk for all-cause mortality ( P =5.7×10 −15 ). Ten additional diet-associated CpGs were nominally associated with all-cause mortality ( P P −4 ). For example, hypermethylation of cg11250194 ( FADS2 ) was associated with lower triglyceride concentrations (MR, P =1.5×10 −14 ).and hypermethylation of cg02079413 ( SNORA54 ; NAP1L4 ) was associated with body mass index (corrected MR, P =1×10 −6 ). Conclusions: Habitual diet quality was associated with differential peripheral leukocyte DNA methylation levels of 30 CpGs, most of which were also associated with multiple health outcomes, in European ancestry individuals. These findings demonstrate that integrative genomic analysis of dietary information may reveal molecular targets for disease prevention and treatment. |
| Databáze: | OpenAIRE |
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