Visceral adiposity and liver fat as mediators of the association between cardiorespiratory fitness and plasma glucose-insulin homeostasis
| Autor: | Caroline Rhéaume, Patrick Mathieu, Paul Poirier, Natalie Alméras, Benoît Lamarche, Eric Larose, Philippe Pibarot, Dominic Chartrand, Jean-Pierre Després |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipose tissue 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Asymptomatic Fats 03 medical and health sciences Electrocardiography 0302 clinical medicine Insulin resistance Liver Function Tests Physiology (medical) Internal medicine medicine Homeostasis Humans Insulin Treadmill Morning Aged business.industry Cardiorespiratory fitness Glucose Tolerance Test Middle Aged medicine.disease Magnetic Resonance Imaging Diet Endocrinology Adipose Tissue Cardiorespiratory Fitness Liver Body Composition Exercise Test Female medicine.symptom Insulin Resistance business hormones hormone substitutes and hormone antagonists |
| Zdroj: | American journal of physiology. Endocrinology and metabolism. 319(3) |
| ISSN: | 1522-1555 |
| Popis: | Cardiorespiratory fitness (CRF) is positively associated with insulin sensitivity, whereas excessive levels of visceral adipose tissue (AT) and liver fat (LF) are both associated with insulin resistance and impaired plasma glucose-insulin homeostasis. To what extent levels of visceral AT and LF content contribute to the relationship between CRF and indices of plasma glucose-insulin homeostasis is uncertain. Our objective was to explore the interactions among CRF, visceral AT, and LF with glucose tolerance/insulin levels in asymptomatic and apparently healthy individuals. CRF was measured in 135 women and 177 men with a maximal treadmill graded exercise test. Indices of plasma glucose-insulin homeostasis were derived from a 3-h oral glucose tolerance test (OGTT) performed in the morning after a 12-h fast. Visceral AT levels and LF content were measured using magnetic resonance imaging and spectroscopy. For any given CRF level, women presented significantly lower visceral AT and LF than men as well as lower homeostasis model assessment of insulin resistance (HOMA-IR) and plasma glucose-insulin levels during the OGTT compared with men. In both sexes, there were significant negative correlations between CRF and HOMA-IR as well as glucose and insulin levels measured during the OGTT. Both glucose and insulin levels during the OGTT correlated positively with visceral AT and LF. In women and men, being in the top CRF tertile was associated with low levels of visceral AT and LF. Multivariable linear regression analyses suggested that visceral AT and LF were plausible mediators of the association between CRF and indices of plasma glucose-insulin homeostasis. |
| Databáze: | OpenAIRE |
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