Evaluation of PCA3 and multiparametric MRI’s: collective benefits before deciding initial prostate biopsy for patients with PSA level between 3-10ng/mL
| Autor: | Hasan Saygin, Guner Sonmez, Ufuk Berber, Ferhat Ateş, Sezgin Okçelik, Hasan Soydan, Kenan Karademir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
PCA3
Male medicine.medical_specialty Prostate biopsy Urology Biopsy Clinical Decision-Making 030232 urology & nephrology lcsh:RC870-923 Risk Assessment 03 medical and health sciences 0302 clinical medicine Prostate Antigens Neoplasm Predictive Value of Tests Reference Values medicine Humans Prospective Studies Prospective cohort study Digital Rectal Examination medicine.diagnostic_test business.industry prostate cancer antigen 3 Age Factors Prostatic Neoplasms Reproducibility of Results Magnetic resonance imaging Rectal examination Organ Size Middle Aged Prostate-Specific Antigen lcsh:Diseases of the genitourinary system. Urology Magnetic Resonance Imaging Surgery medicine.anatomical_structure 030220 oncology & carcinogenesis Predictive value of tests Original Article human [Supplementary Concept] Neoplasm Grading business Nuclear medicine |
| Zdroj: | International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International Brazilian Journal of Urology, Vol 42, Iss 3, Pp 449-455 (2016) International braz j urol v.42 n.3 2016 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International braz j urol, Volume: 42, Issue: 3, Pages: 449-455, Published: JUN 2016 |
| ISSN: | 1677-6119 1677-5538 |
| Popis: | Objective To analyze the contribution of multiparametric MRI and PCA3 assay, pre- decision of initial biopsy in PSA level between 3-10 ng/mL patients with normal digital rectal examination(DRE). Materials and Methods PSA level 3-10 ng/mL ,patients, with normal DRE results and no previous prostate biopsy history, were included in this study. Each patient underwent multiparametric MRI one week before biopsy. Urine sample taking for PCA3 examination preceded the biopsy. Systematic and targeted biopsies were conducted. Patients with high PSA levels were seperated into two groups as: high PCA3 scored and low PCA3 scored. Then each group was divided into two sub-groups as: MRI lesion positive and negative. Tumor incidence, positive predictive values(PPV) and negative predictive values(NPV) were calculated. Results 53 patients were included between February 2013 and March 2014.Mean age 61.22 ± 1.06. Mean PSA value 5.13 ± 0.19 ng / mL. Mean PCA3 score 98.01 ± 23.13 and mean prostate size was 48.96 ± 2.67 grams. Fourty nine patients had both PCA3 score and multiparametric MRI. The PCA3’s PPV value was 58.33%. If multiparametric MRI lesions are added to high PCA3 scores , the PPV appears to elevate to 91.66%. NPV of PCA3 was 96%. NPV was 95% when there was no lesion in the multiparametric MRI with low PCA3 scores. Sensitivity was 91.66% , specificity was 95% respectively. Conclusion Adding multimetric MRI can also support biopsy decision for patients with high PCA3 value. When PCA3 value is low, patients can be survailled without any need to take a MRI. |
| Databáze: | OpenAIRE |
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