Treatment of Periodontal Intrabony Defects Using β-TCP Alone or in Combination with rhPDGF-BB: A Randomized Controlled Clinical and Radiographic Study
| Autor: | Maroo S, Murthy Kr |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Calcium Phosphates Male Radiography medicine.medical_treatment Alveolar Bone Loss Becaplermin Dentistry Bone grafting Alveolar crest Periodontal Attachment Loss medicine Humans Gingival recession business.industry Alveolar Ridge Augmentation Proto-Oncogene Proteins c-sis Resorption Treatment Outcome Clinical attachment loss Guided Tissue Regeneration Periodontal Periodontics Female Rhpdgf bb Oral Surgery medicine.symptom business |
| Zdroj: | The International Journal of Periodontics and Restorative Dentistry. 34:841-847 |
| ISSN: | 0198-7569 |
| DOI: | 10.11607/prd.2030 |
| Popis: | The need to increase the predictability of periodontal regeneration has encouraged clinicians and researchers to employ cell-stimulating proteins in combination with osteoconductive scaffolds, based on the principles of tissue engineering. The purpose of this clinical and radiographic study was to compare the regenerative potential of the combination of β-tricalcium phosphate (β-TCP) and recombinant human platelet-derived growth factor BB (rhPDGF-BB) in the grafting of intraosseous defects with the established technique of bone grafting with (β-TCP alone. A total of 30 sites from 15 patients with infrabony defects in two different quadrants were selected, and the sites were randomly divided into test sites (rhPDGF + β-TCP) and control sites (β-TCP alone) using a split-mouth design. Clinical parameters, including probing pocket depth, clinical attachment level, and gingival recession, were recorded at baseline, 6 months, and 9 months. Radiographic evaluation was carried out to evaluate defect fill, change in alveolar crest height, and percentage of defect fill at baseline, 6 months, and 9 months. Both the experimental groups showed statistically significant reduction in probing pocket depth and gain in clinical attachment level. On intergroup comparison, sites treated with rhPDGF + β-TCP demonstrated a significantly greater pocket depth reduction (P < .05) and greater gain in clinical attachment level (P < .01). Mean percentage defect fill was significantly greater in test sites as compared with control sites at 6 and 9 months (P < .01). rhPDGF + β-TCP-treated sites demonstrated a significant gain in mean alveolar crest height at 6 and 9 months (P < .05), while β-TCP-treated sites demonstrated crestal resorption. Both groups demonstrated potential in enhancing periodontal regeneration; however, on comparison between the two groups, the results obtained by rhPDGF + β-TCP were significantly better with respect to both clinical and radiographic parameters. |
| Databáze: | OpenAIRE |
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