Abundance of estrogen receptors involved in non-canonical signaling in the dog testis
| Autor: | Agnieszka Pietsch-Fulbiszewska, Malgorzata Kotula-Balak, Michal Duliban, Anna Galuszka, Piotr Pawlicki, Grzegorz Ramisz, Wiktor Turek, Klaudia Dubniewicz, Maria Chmurska-Gąsowska, Laura Pardyak |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
tumor medicine.medical_specialty Membrane estrogen receptor G-protein-coupled estrogen receptor Testicular Germ Cell Tumor estrogen-related receptor Estrogen receptor testis Estrogen-related receptor Endocrinology Dogs Food Animals Internal medicine Testis medicine Animals Receptor Chemistry General Medicine medicine.disease Receptors Estrogen Sex steroid dog Animal Science and Zoology Germ cell tumors GPER Signal Transduction |
| Zdroj: | Animal reproduction science. 235 |
| ISSN: | 1873-2232 |
| Popis: | With estrogen regulation of the reproductive system, G-protein-coupled membrane estrogen receptor (GPER) and estrogen-related receptors (ERRs) are implicated. Non-canonical receptors can bind estrogens such as environmental and pharmacological chemicals. These compounds induce rapid non-genomic pathways or receptor interaction including autoactivation. Testicular tumors occur in dogs more frequently than in other domestic animals. Also, in recent decades there were increased occurrences of various tumor types in dogs. Using qRT-PCR, Western blot and immunohistochemistry procedures in the present study, there was determination of abundance pattern of GPER, ERRα, β and γ in dog tests when there were intratubular germ cell tumors. There was quantitation of estradiol, cyclic GMP and calcium ions (Ca2+). There were changes (P |
| Databáze: | OpenAIRE |
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