Gray matter anomalies in anterior cingulate cortex as a correlate of depressive symptoms in drug-naïve idiopathic restless legs syndrome
| Autor: | Huifang Shang, HaiCun Shi, Congsong Dong, G.L. Zhou, ZhenYu Dai, PingLei Pan, JianGuo Zhong, wenchun song, PeiRong Xiao |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Gyrus Cinguli Neuroimaging Restless Legs Syndrome Internal medicine mental disorders Image Processing Computer-Assisted medicine Humans In patient Restless legs syndrome Gray Matter Psychiatry Anterior cingulate cortex Depressive symptoms Depression General Neuroscience Voxel-based morphometry Middle Aged medicine.disease Magnetic Resonance Imaging Drug-naïve medicine.anatomical_structure Regression Analysis Treatment strategy Female Atrophy Psychology medicine.drug |
| Zdroj: | Neuroscience. 277:1-5 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2014.06.045 |
| Popis: | Background Depressive symptoms are frequent in idiopathic restless legs syndrome (RLS). However, little is known, so far, about the neurological basis. The present study aimed to explore the neuroanatomical anomalies in depressed drug-naive RLS patients using voxel-based morphometry (VBM) analysis. Methods We recruited 16 drug-naive idiopathic RLS patients with depressive symptoms (RLS-D), 18 drug-naive idiopathic RLS patients without depressive symptoms (RLS-ND), and 18 normal controls. All participants underwent structural MRI scans on a 3-T MR system. The differences in regional gray matter (GM) density were determined across groups by VBM8. Additional regression analysis was used to identify any associations between regional GM density and clinical symptoms. Results GM density of the bilateral anterior cingulate cortex (ACC) was significantly reduced in RLS-D patients when compared to RLS-ND patients or to the healthy controls. However, there were no significant differences of GM density either when the whole RLS group or the RLS-ND group was compared to healthy controls, respectively. Particularly, we found GM density of right ACC was negatively correlated with the severity and duration of depressive symptoms in RLS-D patients. Conclusions Depressive symptoms are associated with GM anomalies in ACC in patients with RLS. We propose that ACC is perhaps an important neuroimaging marker for facilitating treatment strategies in patients with RLS when assessing depressive symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect