Impact of 18F-FDG-PET/CT on treatment strategy in colorectal cancer lung metastasis before lung radiofrequency ablation
| Autor: | Kan Takeda, Haruyuki Takaki, Naohisa Suzawa, Koichiro Yamakado, Hiroshi Kodama, Tomomi Yamada |
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| Rok vydání: | 2013 |
| Předmět: |
Ablation Techniques
Adult Male Oncology medicine.medical_specialty Lung Neoplasms Radiofrequency ablation Colorectal cancer Lung metastasis Multimodal Imaging law.invention Fluorodeoxyglucose F18 law Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Aged Aged 80 and over Incidental Findings Lung medicine.diagnostic_test business.industry General Medicine Middle Aged Radiofrequency Therapy medicine.disease medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Female Fdg pet ct Radiology Colorectal Neoplasms Tomography X-Ray Computed business |
| Zdroj: | Nuclear Medicine Communications. 34:689-693 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/mnm.0b013e328361cd28 |
| Popis: | The aim of the study was to evaluate prospectively the clinical impact of 2-(F)-fluoro-2-deoxy-D-glucose (F-FDG) PET/computed tomography (CT) on the pretreatment assessment of patients with colorectal lung metastasis before radiofrequency (RF) ablation.The institutional review board approved this prospective study. The eligibility criteria for lung RF ablation were the presence of five or fewer colorectal lung metastases with a maximum tumor size of 3 cm and absence of extrapulmonary lesions. Lung RF ablation candidates who underwent pretreatment PET/CT studies were included. The incidence of detection of unexpected recurrent lesions on PET/CT was evaluated, along with its impact on subsequent treatments. Factors linked with the incidence of unexpected recurrent lesions were evaluated using univariate and multivariate analyses.Between October 2008 and June 2011, 60 patients were enrolled. Among the unexpected abnormal F-FDG accumulations found in 13 patients (21.7%), presence of extrapulmonary lesions was proved in 12 patients (20.0%, 12/60), prompting treatment strategy changes. One false-positive case was found (1.7%, 1/60). The sensitivity, specificity, and accuracy in detecting unexpected lesions by PET/CT were, respectively, 100, 97.9, and 98.3%. Elevation of the serum carcinoembryonic antigen level (6.0 ng/ml) was the only significant factor linked with unexpected lesions in both univariate (P=0.02) and multivariate analyses (P=0.02).A PET/CT study should be performed in patients with colorectal lung metastasis before selecting them for lung RF ablation, especially when the carcinoembryonic antigen level is elevated. |
| Databáze: | OpenAIRE |
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