Identification of a Sorbicillinoid-Producing Aspergillus Strain with Antimicrobial Activity Against Staphylococcus aureus: a New Polyextremophilic Marine Fungus from Barents Sea
| Autor: | Paulina Corral, Giovanna Cristina Varese, Luciana Tartaglione, Pietro Tedesco, Emiliana Tortorella, Maria Valeria D'Auria, Carmen Festa, Giorgio Gnavi, Donatella de Pascale, Fortunato Palma Esposito, Angela Falco |
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| Přispěvatelé: | Corral, Paulina, PALMA ESPOSITO, Fortunato, Tedesco, Pietro, Falco, Angela, Tortorella, Emiliana, Tartaglione, Luciana, Festa, Carmen, D’Auria, Maria Valeria, Gnavi, Giorgio, Varese, Giovanna Cristina, de Pascale, Donatella |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Geologic Sediments Staphylococcus aureus Oceans and Seas 030106 microbiology Microbial Sensitivity Tests Fungus Alkenes Aquatic Science Antimicrobial activity Biology Applied Microbiology and Biotechnology Sediments 03 medical and health sciences Minimum inhibitory concentration Bisvertinolone Barents Sea MDR Marine fungi Food science Aspergillus protuberu Psychrophile Marine fungi Aspergillus protuberus Bisvertinolone Antimicrobial activity MDR bacteria Sediments Barents Sea Aspergillus protuberus Aspergillus Bacteria Cyclohexanones MDR bacteria Fungi biology.organism_classification Antimicrobial Anti-Bacterial Agents 030104 developmental biology Sediment Antibacterial activity Biotechnology |
| Zdroj: | Marine Biotechnology Marine biotechnology (2018): 1–10. doi:10.1007/s10126-018-9821-9 info:cnr-pdr/source/autori:Corral, Paulina; Corral, Paulina; Esposito, Fortunato Palma; Tedesco, Pietro; Falco, Angela; Tortorella, Emiliana; Tartaglione, Luciana; Festa, Carmen; D'Auria, Maria Valeria; Gnavi, Giorgio; Varese, Giovanna Cristina; de Pascale, Donatella/titolo:Identification of a Sorbicillinoid-Producing Aspergillus Strain with Antimicrobial Activity Against Staphylococcus aureus: a New Polyextremophilic Marine Fungus from Barents Sea/doi:10.1007%2Fs10126-018-9821-9/rivista:Marine biotechnology (Print)/anno:2018/pagina_da:1/pagina_a:10/intervallo_pagine:1–10/volume |
| ISSN: | 1436-2228 |
| DOI: | 10.1007/s10126-018-9821-9 |
| Popis: | The exploration of poorly studied areas of Earth can highly increase the possibility to discover novel bioactive compounds. In this study, the cultivable fraction of fungi and bacteria from Barents Sea sediments has been studied to mine new bioactive molecules with antibacterial activity against a panel of human pathogens. We isolated diverse strains of psychrophilic and halophilic bacteria and fungi from a collection of nine samples from sea sediment. Following a full bioassay-guided approach, we isolated a new promising polyextremophilic marine fungus strain 8Na, identified as Aspergillusprotuberus MUT 3638, possessing the potential to produce antimicrobial agents. This fungus, isolated from cold seawater, was able to grow in a wide range of salinity, pH and temperatures. The growth conditions were optimised and scaled to fermentation, and its produced extract was subjected to chemical analysis. The active component was identified as bisvertinolone, a member of sorbicillonoid family that was found to display significant activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 30 μg/mL. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. |
| Databáze: | OpenAIRE |
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