Supplementary Methods, Figures 1-6 Supplemental Tables 1-2 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors

Autor: Robyn L. Ward, Jason W.H. Wong, Michael J. Bourke, Nicholas J. Hawkins, Mathew A. Sloane, John E. Pimanda, Caroline E. Ford, Ashraf Dower, Regina Ryan, Dominik Beck, Andrea C. Nunez, Deborah Packham, Chau-To Kwok, Sameer Srivastava, Peter Zarzour, Benedict Ng, Luke B. Hesson
Rok vydání: 2023
Popis: Supplementary Figure S1. LSTs profiled in this study. Supplementary Figure S2. Mutation validation by Sanger sequencing. Supplementary Figure S3. Analytical strategy for identifying LST driver genes and significantly altered pathways. Supplementary Figure S4. Comparison of methylation events in LSTs and CRCs. Supplementary Figure S5. Epigenetic inactivation of SLITRK5 occurs frequently in LSTs and CRC cell lines. Supplementary Figure S6. Surface morphology and histopathological subtype correlates with the frequency of KRAS mutations. Supplementary Table S1. Clinicopathological characteristics of the eleven LSTs profiled in this study. Supplementary Supplementary Table S2. Clinicopathological characteristics of Validation Cohorts 1 and 2. Supplementary Table S3. Whole exome sequencing data. Supplementary Table S4. Summary of epigenetic and gene expression data.
Databáze: OpenAIRE