Interleukin-15 and irisin serum concentrations are not related to cardiometabolic risk factors in patients with type 2 diabetes from Korea and Germany
| Autor: | Ji A Seo, Sin Gon Kim, Nam Hoon Kim, Kyungdo Han, Thomas Ebert, Sei Hyun Baik, Nan Hee Kim, Hye Jin Yoo, Matthias Blüher, Mathias Fasshauer, Kyung Mook Choi, Soon Young Hwang, Hye Soo Chung |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Endocrinology Diabetes and Metabolism Short Communication Interleukin Skeletal muscle 030209 endocrinology & metabolism Physical exercise General Medicine White adipose tissue Type 2 diabetes 030204 cardiovascular system & hematology medicine.disease FNDC5 03 medical and health sciences 0302 clinical medicine Endocrinology medicine.anatomical_structure Diabetes mellitus Internal medicine Myokine Internal Medicine medicine business |
| Zdroj: | Acta Diabetologica |
| ISSN: | 1432-5233 0940-5429 |
| Popis: | Physical exercise plays an important role in both the prevention and treatment of cardiometabolic diseases. Peptides secreted or released from skeletal muscle, so-called myokines, contribute to the beneficial anti-inflammatory and insulin-sensitizing effects of increased muscle activity and may, therefore, counteract pathomechanisms of obesity and type 2 diabetes (T2D) [1]. However, the impact of myokines including interleukin (IL)-6, IL-8, IL-13, IL-15, angiopoietin-like 4 (ANGPTL4), fibroblast growth factors (FGF)-2, FGF-21, and irisin on altered organ cross-talk in cardiometabolic diseases is still poorly understood [1]. Irisin has been described as a protein released from skeletal muscle after physical activity [2] which may, in rodents and more controversially discussed in humans [1], mediate browning of white adipose tissue. Although the existence of circulating human irisin has even been questioned because human FNDC5 has a noncanonical ATA translation start, irisin has been detected in human plasma using mass spectrometry with appropriate control peptides [3]. IL-15 increases upon both aerobic and resistance exercise and exerts beneficial metabolic effects in patients with obesity and T2D [1]. IL-15 inhibits lipogenesis, induces fat oxidation, enhances energy expenditure, and improves insulin sensitivity and glucose metabolism [4]. To better understand the potential role of these myokines in T2D, we tested the hypotheses that IL-15 and irisin serum concentrations correlate with cardiometabolic risk parameters and are different in subgroups of T2D patients with or without diabetes complications independently of ethnicity. |
| Databáze: | OpenAIRE |
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