Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson’s disease

Autor: Zoe Joanna Syrimi, Ilona Eliasova, Lubomír Vojtíšek, Alena Svátková, Jana Viskova, Irena Rektorová, Jiri Vanicek
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Pathology
Parkinson's disease
Precuneus
Motor Activity
Severity of Illness Index
03 medical and health sciences
Superior temporal gyrus
Imaging
Three-Dimensional
0302 clinical medicine
Supramarginal gyrus
Internal medicine
Image Processing
Computer-Assisted
medicine
Humans
Dementia
Effects of sleep deprivation on cognitive performance
Biological Psychiatry
Aged
Cerebral Cortex
Parkinson Disease
medicine.disease
Magnetic Resonance Imaging
Cerebrovascular Disorders
Psychiatry and Mental health
Cross-Sectional Studies
030104 developmental biology
medicine.anatomical_structure
Neurology
Cerebral blood flow
Cerebrovascular Circulation
Posterior cingulate
Cardiology
Female
Spin Labels
Neurology (clinical)
Psychology
030217 neurology & neurosurgery
Zdroj: Journal of Neural Transmission. 124:551-557
ISSN: 1435-1463
0300-9564
Popis: While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years ± 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years ± 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software. Associations between the ASL values in volumes of interest (VOIs) and behavioural and cognitive measures were assessed by Spearman correlation analysis. Posterior cortical hypoperfusion was found in PD patients compared to HC in the left supramarginal gyrus/superior temporal gyrus (VOI1) and left posterior cingulate/precuneus (VOI2). Positive correlation was revealed between perfusion in the VOI2 and Addenbrooke's Cognitive Examination Revised (ACE-R) scores after filtering out the effect of age, levodopa equivalent dose (LED), and total intracranial volume (TIV) (R = 0.51, p = 0.04). Conversely, negative correlation between VOI1 and ACE-R was detected (R = -0.62, p = 0.01) after regressing out the effects of motor impairment, age, LED, and TIV. In non-demented subjects with PD, blood flow abnormalities in precuneus/posterior cingulate were linked to the level of motor impairment and global cognitive performance. Oppositely, perfusion abnormalities in supramarginal gyrus might serve as a compensatory mechanism for brain degeneration and decreased cognitive performance.
Databáze: OpenAIRE
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