Development and characterization of a coronary polylactic acid stent prototype generated by selective laser melting
| Autor: | Rüdiger Blindt, Rainer Hoffmann, Wilhelm Meiners, Vera A. Schulte, Lucas Jauer, Reinhart Poprawe, Christian Flege, Simon Höges, Konrad Wissenbach, Felix Vogt, Mauricio Borinski, Monika Jobmann |
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| Rok vydání: | 2012 |
| Předmět: |
Materials science
Biocompatibility Polymers Polyesters medicine.medical_treatment Biomedical Engineering Biophysics Biocompatible Materials Bioengineering Cell morphology Muscle Smooth Vascular Biomaterials chemistry.chemical_compound Restenosis Polylactic acid Coronary stent medicine Humans Lactic Acid Selective laser melting Cells Cultured Lasers Coronary Stenosis Stent equipment and supplies medicine.disease Biodegradable polymer Microscopy Fluorescence chemistry Chromatography Gel Microscopy Electron Scanning Stents Biomedical engineering |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 24:241-255 |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-012-4779-z |
| Popis: | In-stent restenosis is still an important issue and stent thrombosis is an unresolved risk after coronary intervention. Biodegradable stents would provide initial scaffolding of the stenosed segment and disappear subsequently. The additive manufacturing technology Selective Laser Melting (SLM) enables rapid, parallel, and raw material saving generation of complex 3- dimensional structures with extensive geometric freedom and is currently in use in orthopedic or dental applications. Here, SLM process parameters were adapted for poly-L-lactid acid (PLLA) and PLLA-co-poly-ε-caprolactone (PCL) powders to generate degradable coronary stent prototypes. Biocompatibility of both polymers was evidenced by assessment of cell morphology and of metabolic and adhesive activity at direct and indirect contact with human coronary artery smooth muscle cells, umbilical vein endothelial cells, and endothelial progenitor cells. γ-sterilization was demonstrated to guarantee safety of SLM-processed parts. From PLLA and PCL, stent prototypes were successfully generated and post-processing by spray- and dip-coating proved to thoroughly smoothen stent surfaces. In conclusion, for the first time, biodegradable polymers and the SLM technique were combined for the manufacturing of customized biodegradable coronary artery stent prototypes. SLM is advocated for the development of biodegradable coronary PLLA and PCL stents, potentially optimized for future bifurcation applications. |
| Databáze: | OpenAIRE |
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