Chromium(III) Glycinate Complex Supplementation Improves the Blood Glucose Level and Attenuates the Tissular Copper to Zinc Ratio in Rats with Mild Hyperglycaemia

Autor: Monika Okulicz, Ewelina Król, Zbigniew Krejpcio, Hanna Śmigielska
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Molar
Chromium
Male
medicine.medical_specialty
Chromium(III) picolinate
Supplementation
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Glycine
chemistry.chemical_element
Zinc
010501 environmental sciences
01 natural sciences
Biochemistry
Article
Diabetes Mellitus
Experimental
Inorganic Chemistry
03 medical and health sciences
chemistry.chemical_compound
Coordination Complexes
Internal medicine
Healthy control
medicine
Hyperglycaemia
Animals
Hypoglycemic Agents
Rats
Wistar
0105 earth and related environmental sciences
0303 health sciences
Kidney
Chromium(III) glycinate complex
Chemistry
Cholesterol
030302 biochemistry & molecular biology
Biochemistry (medical)
General Medicine
Streptozotocin
Copper
Rats
Endocrinology
medicine.anatomical_structure
Hyperglycemia
Diabetic rats
medicine.drug
Zdroj: Biological Trace Element Research
ISSN: 1559-0720
0163-4984
Popis: The aim of the study was to evaluate the hypoglycaemic potential of supplementary Cr in the form of chromium(III) glycinate (CrGly) in the diabetic model of rats. The experiment was conducted on 40 male Wistar rats, of which 30 were made diabetic by injection of a single dose of streptozotocin (55 mg/kg b.m.), while the remaining 10 rats served as the healthy control. After inducing hyperglycaemia, 2 groups of diabetic rats (10 rats each) were supplemented with Cr either as CrGly or chromium(III) picolinate (CrPic) given orally at a dose of 10 mg/kg diet (about 0.75 mg Cr/kg b.m.) with adequate AIN-93M diet for 7 weeks. At the termination of experiment, all animals were sacrificed to collect blood and internal organs for biochemical assays. Blood biochemical indices and tissular trace element contents (Fe, Zn, Cu, Cr) were measured and compared with the values of the untreated groups. It was found that CrGly significantly decreased blood glucose, total cholesterol, HDL cholesterol and triacylglycerol levels more efficiently than CrPic. Furthermore, both Cr compounds normalized disturbed the serum, renal and cardiac molar Cu/Zn ratio, as well as restored the kidney Zn and Cu levels in rats with hyperglycaemia. Supplementary Cr did not increase the tissular Cr levels in diabetic rats. The study confirmed the hypoglycaemic potential of CrGly in the diabetic model of rats.
Databáze: OpenAIRE
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