An Investigation of the Association Between Vascular Endothelial Growth Factor +405 G/C Polymorphism and Acute Liver Transplant Rejection in Iranian Liver Transplant Recipients
| Autor: | Lida Sadeghifard, Ramin Yaghobi, Mohammad Hossein Karimi, Mozhdeh Heidari, Seyed Ali Malek-Hosseini |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Graft Rejection
Vascular Endothelial Growth Factor A medicine.medical_specialty Genotype medicine.medical_treatment Iran Polymorphism Single Nucleotide Gastroenterology chemistry.chemical_compound Liver disease Interstitial matrix Polymorphism (computer science) Internal medicine medicine Humans Transplantation business.industry Liver Diseases Growth factor medicine.disease Liver Transplantation Endothelial stem cell Vascular endothelial growth factor Treatment Outcome chemistry Gene polymorphism business |
| Zdroj: | Experimental and Clinical Transplantation. 20:564-568 |
| ISSN: | 2146-8427 1304-0855 |
| DOI: | 10.6002/ect.2020.0515 |
| Popis: | OBJECTIVES Vascular endothelial growth factor is an endothelial-specific growth factor that promotes endothelial cell proliferation, differentiation, and survival; mediates endothelium-dependent vasodilatation; induces microvascular hyperpermeability; and participates in interstitial matrix remodeling. The aim of the present study was to investigate the association between +405 G/C polymorphism of vascular endothelial growth factor and the risk of liver rejection in liver transplant recipients. MATERIALS AND METHODS The present study included 124 patients with liver disease that led to liver transplant. There were 22 patients who experienced histologically proven acute liver rejection, and the other 102 patients showed no rejection. Both groups were matched for sex and age. The VEGF+405 G/C polymorphism was evaluated by the polymerase chain reaction-restriction fragment-length polymorphism method. RESULTS Our analyses showed no significant relationships between genotypes and alleles of +405 G/C and risk of acute liver transplant rejection. CONCLUSIONS Our report indicated that there was no association between the carrier states of +405 G/C gene polymorphism of vascular endothelial growth factor and acute rejection or nonrejection of liver transplant. |
| Databáze: | OpenAIRE |
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