Usefulness of total cholesterol/HDL-cholesterol ratio in the management of diabetic dyslipidaemia
| Autor: | M. A. Sancho-Serrano, J. A. Gimeno-Orna, E. Faure-Nogueras |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Hyperlipidemias Gastroenterology chemistry.chemical_compound Endocrinology Diabetes mellitus Internal medicine Total cholesterol Internal Medicine medicine Humans Prospective cohort study Cholesterol business.industry Cholesterol HDL Hazard ratio Middle Aged medicine.disease Confidence interval Diabetes Mellitus Type 2 chemistry HDL/cholesterol ratio Relative risk Female lipids (amino acids peptides and proteins) Epidemiologic Methods business Diabetic Angiopathies |
| Zdroj: | Diabetic Medicine. 22:26-31 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.2004.01341.x |
| Popis: | Our aim was to evaluate the usefulness of the total cholesterol/HDL-cholesterol ratio (TC/HDL) in predicting the cardiovascular risk of Type 2 diabetic patients.Prospective cohort study with inclusion of 418 Type 2 diabetic individuals with follow-up until the appearance of a cardiovascular event. The predictive power of updated mean lipid values during follow-up was analysed by means of Cox proportional hazard models. An estimate was made of the relative risk (RR) conferred by high levels of TC/HDL stratified by LDL-cholesterol levels.Sixty-six cardiovascular events occurred during an average follow-up of 4.7 years (sd 1.5). The main lipid predictor of vascular events was mean TC/HDL ratio [hazard ratio (HR) = 1.46; 95% confidence interval (CI) 1.25, 1.7; P0.0001]. In the multivariate model with simultaneous inclusion of mean TC/HDL and mean LDL-cholesterol, both were significant predictors of cardiovascular disease [HR (1 unit) = 1.37; 95% CI 1.16, 1.62; P = 0.0003 and HR (1 mmol/l) = 1.5; 95% CI 1.04, 2.18; P = 0.03, respectively]. The LDL adjusted RR for cardiovascular events due to high TC/HDL ratio, with 4.5 cut-off point, was 2.5 (95% CI 1.4, 4.3; P = 0.0007). For the stratum of subjects with average LDL cholesterol3.5 mmol/l, RR was 1.2 (95% CI 0.5, 2.8; P = NS) and for the stratum of average LDL cholesterol3.5 mmol/l, RR was 4 (95% CI 1.8, 9; P = 0.00013), with heterogeneity among strata (P = 0.044).It could be useful to include the TC/HDL ratio in treatment guides for diabetic dyslipidaemia, given their high predictive value and strong interaction with LDL cholesterol. |
| Databáze: | OpenAIRE |
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